Mehrdad Roghani1, Tourandokht Baluchnejadmojarad. 1. Department of Physiology and Medical Research Center, School of Medicine and Medicinal Plant Research Center, Shahed University, Tehran, Iran.
Abstract
BACKGROUND AND OBJECTIVE: Green tea catechins including epigallocatechin-3-gallate (EGCG) could exert beneficial health effects to ameliorate metabolic diseases. The effect of chronic administration of EGCG was evaluated on serum glucose and lipid profile and hepatic lipid peroxidation in streptozotocin (STZ)-diabetic rats. MATERIALS AND METHODS: Rats received EGCG 25mg/kg/day for 8 weeks 1 week after diabetes induction. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels and MDA level and SOD activity in hepatic tissue were spectrophotometrically measured. RESULTS: Treatment of diabetic rats with EGCG produced a hypoglycemic effect and there were appropriate changes regarding serum lipids in treated diabetic group. Meanwhile, EGCG treatment attenuated the increased MDA content and reduced activity of SOD in liver. CONCLUSION: Chronic treatment of diabetic rats with EGCG could prevent abnormal changes in blood glucose and lipid profile and attenuat hepatic lipid peroxidation.
BACKGROUND AND OBJECTIVE: Green tea catechins including epigallocatechin-3-gallate (EGCG) could exert beneficial health effects to ameliorate metabolic diseases. The effect of chronic administration of EGCG was evaluated on serum glucose and lipid profile and hepatic lipid peroxidation in streptozotocin (STZ)-diabeticrats. MATERIALS AND METHODS:Rats received EGCG 25mg/kg/day for 8 weeks 1 week after diabetes induction. Serum glucose, triglyceride, total cholesterol, HDL- and LDL-cholesterol levels and MDA level and SOD activity in hepatic tissue were spectrophotometrically measured. RESULTS: Treatment of diabeticrats with EGCG produced a hypoglycemic effect and there were appropriate changes regarding serum lipids in treated diabetic group. Meanwhile, EGCG treatment attenuated the increased MDA content and reduced activity of SOD in liver. CONCLUSION: Chronic treatment of diabeticrats with EGCG could prevent abnormal changes in blood glucose and lipid profile and attenuat hepatic lipid peroxidation.
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