Literature DB >> 19682511

Involvement of mitochondrial permeability transition in hepatitis B virus replication.

Chang Tan1, Hua Guo, Maofa Zheng, Yu Chen, Weida Huang.   

Abstract

The HBx protein of human hepatitis B virus (HBV) activates a calcium-dependent kinase pathway which is essential for the viral replication. In this study, we found that HBx expression in the absence of other HBV proteins and in the context of HBV replication decreased the mitochondrial calcein-AM/CoCl(2) signals by 10% and 14% in HepG2 cells and by 15% and 10% in Huh7 cells, respectively. This indicates that HBx can induce mitochondrial permeability transition (MPT) and cause calcium effusion into the plasma. In addition, RNA interference of Cylophilin D decreased HBx-induced MPT and suppressed HBV DNA replication by 41% in HepG2 cells. Our results suggest that HBx expression can induce MPT and facilitate HBV DNA replication.

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Year:  2009        PMID： 19682511     DOI： 10.1016/j.virusres.2009.08.001

Source DB:  PubMed          Journal:  Virus Res        ISSN： 0168-1702            Impact factor:   3.303


  10 in total

Review 1.  Hepatitis B virus X gene and hepatocarcinogenesis.

Authors:  Sue-Ann Ng; Caroline Lee
Journal:  J Gastroenterol       Date:  2011-06-08       Impact factor: 7.527

2.  The C-terminal region of the hepatitis B virus X protein is essential for its stability and function.

Authors:  Rebecca A Lizzano; Bei Yang; Amy J Clippinger; Michael J Bouchard
Journal:  Virus Res       Date:  2010-10-20       Impact factor: 3.303

3.  White spot syndrome virus induces metabolic changes resembling the warburg effect in shrimp hemocytes in the early stage of infection.

Authors:  I-Tung Chen; Takashi Aoki; Yun-Tzu Huang; Ikuo Hirono; Tsan-Chi Chen; Jiun-Yan Huang; Geen-Dong Chang; Chu-Fang Lo; Han-Ching Wang
Journal:  J Virol       Date:  2011-10-05       Impact factor: 5.103

Review 4.  MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma: current status and future prospects.

Authors:  Yi Lin Jane Tan; Wei Ning Chen
Journal:  World J Gastroenterol       Date:  2014-05-28       Impact factor: 5.742

5.  Changes in Mitochondrial Toxicity in Peripheral Blood Mononuclear Cells During Four-Year Administration of Entecavir Monotherapy in Chinese Patients with Chronic Hepatitis B.

Authors:  Li Zhou; Xiaoyu Liu; Feng Ren; Yu Chen; Sujun Zheng; Yuanping Han; Caiyan Zhao; Zhongping Duan
Journal:  Med Sci Monit       Date:  2015-07-15

6.  Hepatitis B virus modulates store-operated calcium entry to enhance viral replication in primary hepatocytes.

Authors:  Jessica C Casciano; Nicholas J Duchemin; R Jason Lamontagne; Laura F Steel; Michael J Bouchard
Journal:  PLoS One       Date:  2017-02-02       Impact factor: 3.240

7.  HBx gene transfection affects the cycle of primary renal tubular epithelial cells through regulating cyclin expression.

Authors:  Wenlun Han; Meiliang Luo; Mengying He; Yunyun Zhu; Yu Zhong; Huideng Ding; Gang Hu; Liansheng Liu; Qin Chen; Ying Lu
Journal:  Mol Med Rep       Date:  2018-06-20       Impact factor: 2.952

Review 8.  Mitochondria and viruses.

Authors:  Akane Ohta; Yukihiro Nishiyama
Journal:  Mitochondrion       Date:  2010-09-08       Impact factor: 4.160

9.  Inhibition of Protease Activated Receptor 2 Attenuates HBx-Induced Inflammation and Mitochondria Oxidative Stress.

Authors:  Bin Li; Yonggang Li; Shuhua Li; Hongwei Li; Ling Liu; Yao Xu
Journal:  Infect Drug Resist       Date:  2022-03-10       Impact factor: 4.003

10.  A direct role for hepatitis B virus X protein in inducing mitochondrial membrane permeabilization.

Authors:  H-R Lee; Y Y Cho; G Y Lee; D-G You; Y D Yoo; Y J Kim
Journal:  J Viral Hepat       Date:  2018-01-24       Impact factor: 3.728
  10 in total

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