Possible involvement of Na+,K(+)-ATPase inhibition in neurotransmitter release induced by collidine.

Previous histochemical studies have demonstrated that collidine abolished the osmiophilia and the chromaffin reaction of the synaptic vesicles, an effect which was ascribed to the release of stored neurotransmitters. Other studies indicated a relationship between the inhibition of Na+,K(+)-ATPase and the release of neurotransmitters. In the present study it is shown that collidine inhibits cation-stimulated ATPase activities of the brain synaptosomal membranes. This favours the idea that neurotransmitter release induced by collidine could be due to the inhibition of Na+,K(+)-ATPase activity.