| Literature DB >> 19679470 |
Jingbo Chen1, Zhuxian Sun, Yanli Zhang, Xianghui Zeng, Chen Qing, Jianping Liu, Liang Li, Hongbin Zhang.
Abstract
A series of gibberellin based molecules were designed and synthesized. Gibberellin derivatives bearing two alpha,beta-unsaturated ketone units showed strong anticancer activities in MTT assay towards a number of human cancer cell lines including HT29, A549, HepG2 and MKN28. The most potent gibberellin derivative (compound 10, IC(50)=2.9 microM against HT29) inhibited completely the topoisomerase I activity at 8 microg/mL level.Entities:
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Year: 2009 PMID： 19679470 DOI： 10.1016/j.bmcl.2009.07.090
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823