Literature DB >> 19679456

Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.

Deepak Kumar1, Sumana Mallick, Joseph R Vedasiromoni, Bikas C Pal.   

Abstract

The methanolic extract of Dillenia indica L. fruits showed significant anti-leukemic activity in human leukemic cell lines U937, HL60 and K562. This finding led to fractionation of the methanolic extract, on the basis of polarity, in which the ethyl acetate fraction showed the highest anti-leukemic activity. A major compound, betulinic acid, was isolated from the ethyl acetate fraction by silica gel column chromatography and was identified and characterized. Betulinic acid could explain the anti-leukemic activity of the methanolic extract and the ethyl acetate fraction. Hence the quantitative estimation of betulinic acid was approached in methanolic extract and fractions using HPLC. Copyright 2009 Elsevier GmbH. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19679456     DOI： 10.1016/j.phymed.2009.07.010

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  13 in total

Review 1.  Plant triterpenoid saponins: biosynthesis, in vitro production, and pharmacological relevance.

Authors:  Tanya Biswas; Upendra N Dwivedi
Journal:  Protoplasma       Date:  2019-07-11       Impact factor: 3.356

2.  Dillenia indica L. attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in STZ-nicotinamide induced diabetic rats.

Authors:  Navpreet Kaur; Lalit Kishore; Randhir Singh
Journal:  J Tradit Complement Med       Date:  2017-06-21

3.  Rutamarin, an Active Constituent from Ruta angustifolia Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.

Authors:  Shafinah Ahmad Suhaimi; Sok Lai Hong; Sri Nurestri Abdul Malek
Journal:  Pharmacogn Mag       Date:  2017-07-11       Impact factor: 1.085

4.  Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology.

Authors:  Fernanda Carolina Sousa Fonseca; Letícia Caribé Batista Reis; Jener David Gonçalves Dos Santos; Carla Rodrigues Cardoso Branco; Sergio Luis da Costa Ferreira; Jorge Mauricio David; Alexsandro Branco
Journal:  Pharmacogn Mag       Date:  2017-04-18       Impact factor: 1.085

5.  Inhibitory effect of triterpenoids from Dillenia serrata (Dilleniaceae) on prostaglandin E2 production and quantitative HPLC analysis of its koetjapic acid and betulinic acid contents.

Authors:  Juriyati Jalil; Carla W Sabandar; Norizan Ahmat; Jamia A Jamal; Ibrahim Jantan; Nor-Ashila Aladdin; Kartiniwati Muhammad; Fhataheya Buang; Hazni Falina Mohamad; Idin Sahidin
Journal:  Molecules       Date:  2015-02-16       Impact factor: 4.411

6.  Study of the potential adverse effects caused by the dermal application of Dillenia indica L. fruit extract standardized to betulinic acid in rodents.

Authors:  Flávia S Fernandes; Gustavo S da Silva; Alexandre S Hilel; Ana C Carvalho; Karina V T Remor; Aline D Schlindwein; Luiz A Kanis; Daniel F Martins; Maicon R Kviecinski
Journal:  PLoS One       Date:  2019-05-31       Impact factor: 3.240

7.  Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.

Authors:  Shreya S Bellampalli; Yingshi Ji; Aubin Moutal; Song Cai; E M Kithsiri Wijeratne; Maria A Gandini; Jie Yu; Aude Chefdeville; Angie Dorame; Lindsey A Chew; Cynthia L Madura; Shizhen Luo; Gabriella Molnar; May Khanna; John M Streicher; Gerald W Zamponi; A A Leslie Gunatilaka; Rajesh Khanna
Journal:  Pain       Date:  2019-01       Impact factor: 7.926

8.  Appraisals of Bangladeshi Medicinal Plants Used by Folk Medicine Practitioners in the Prevention and Management of Malignant Neoplastic Diseases.

Authors:  Md Nur Kabidul Azam; Md Mizanur Rahman; Samanta Biswas; Md Nasir Ahmed
Journal:  Int Sch Res Notices       Date:  2016-01-14

9.  Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats.

Authors:  Maicon Roberto Kviecinski; Isabela Machado Barbosa David; Flávia de Souza Fernandes; Marina Dos Reis Correa; Morgana Miranda Clarinda; Amanda Fernandes Freitas; Jane da Silva; Marta Gava; Simony Davet Müller; Drielly Florentino; Fabrícia Petronilho; Diego Moterle; Luiz Alberto Kanis; Rozangela Curi Pedrosa
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503

10.  Effect of 3, hydroxy-lup- 20(29)-en-28-oic acid on 7,12-Dimethylbenz(a) anthracene impaired cellular homeostasis in extrahepatic organs of Sprague Dawley rats.

Authors:  Pardeep Kaur; Rajbir Kaur; Rohit Arora; Saroj Arora
Journal:  J Xenobiot       Date:  2017-04-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.