Literature DB >> 19679263

Using new tools to define the genetic underpinnings of risky traits associated with coronary artery disease: the SardiNIA study.

James B Strait1, Manuela Uda, Edward G Lakatta, Samer S Najjar.   

Abstract

Genomewide association studies are increasingly being applied to search for novel genes that might underlie cardiovascular diseases. In this article, we briefly review the principles that underlie modern genetic analyses and provide several illustrations from the SardiNIA study of genomewide association studies for cardiovascular risk factor traits.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19679263      PMCID： PMC2744138          DOI： 10.1016/j.tcm.2009.05.001

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  40 in total

Review 1.  Linkage disequilibrium: ancient history drives the new genetics.

Authors:  Gonçalo R Abecasis; Debashis Ghosh; Thomas E Nichols
Journal:  Hum Hered       Date:  2005-04-18       Impact factor: 0.444

2.  Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults.

Authors:  Kim Sutton-Tyrrell; Samer S Najjar; Robert M Boudreau; Lakshmi Venkitachalam; Varant Kupelian; Eleanor M Simonsick; Richard Havlik; Edward G Lakatta; Harold Spurgeon; Stephen Kritchevsky; Marco Pahor; Douglas Bauer; Anne Newman
Journal:  Circulation       Date:  2005-06-20       Impact factor: 29.690

3.  Expert consensus document on arterial stiffness: methodological issues and clinical applications.

Authors:  Stephane Laurent; John Cockcroft; Luc Van Bortel; Pierre Boutouyrie; Cristina Giannattasio; Daniel Hayoz; Bruno Pannier; Charalambos Vlachopoulos; Ian Wilkinson; Harry Struijker-Boudier
Journal:  Eur Heart J       Date:  2006-09-25       Impact factor: 29.983

Review 4.  Mechanisms of disease: The genetic basis of coronary heart disease.

Authors:  Iftikhar J Kullo; Keyue Ding
Journal:  Nat Clin Pract Cardiovasc Med       Date:  2007-10

5.  Strategy for detecting susceptibility genes with weak or no marginal effect.

Authors:  S Kotti; H Bickeboller; F Clerget-Darpoux
Journal:  Hum Hered       Date:  2007-02-02       Impact factor: 0.444

Review 6.  The search for human obesity genes.

Authors:  A G Comuzzie; D B Allison
Journal:  Science       Date:  1998-05-29       Impact factor: 47.728

7.  Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population.

Authors:  A Helgadottir; S Gretarsdottir; D St Clair; A Manolescu; J Cheung; G Thorleifsson; A Pasdar; S F A Grant; L J Whalley; H Hakonarson; U Thorsteinsdottir; A Kong; J Gulcher; K Stefansson; M J MacLeod
Journal:  Am J Hum Genet       Date:  2005-01-07       Impact factor: 11.025

8.  A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

Authors:  Timothy M Frayling; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Rachel M Freathy; Cecilia M Lindgren; John R B Perry; Katherine S Elliott; Hana Lango; Nigel W Rayner; Beverley Shields; Lorna W Harries; Jeffrey C Barrett; Sian Ellard; Christopher J Groves; Bridget Knight; Ann-Marie Patch; Andrew R Ness; Shah Ebrahim; Debbie A Lawlor; Susan M Ring; Yoav Ben-Shlomo; Marjo-Riitta Jarvelin; Ulla Sovio; Amanda J Bennett; David Melzer; Luigi Ferrucci; Ruth J F Loos; Inês Barroso; Nicholas J Wareham; Fredrik Karpe; Katharine R Owen; Lon R Cardon; Mark Walker; Graham A Hitman; Colin N A Palmer; Alex S F Doney; Andrew D Morris; George Davey Smith; Andrew T Hattersley; Mark I McCarthy
Journal:  Science       Date:  2007-04-12       Impact factor: 47.728

9.  Heritability of cardiovascular and personality traits in 6,148 Sardinians.

Authors:  Giuseppe Pilia; Wei-Min Chen; Angelo Scuteri; Marco Orrú; Giuseppe Albai; Mariano Dei; Sandra Lai; Gianluca Usala; Monica Lai; Paola Loi; Cinzia Mameli; Loredana Vacca; Manila Deiana; Nazario Olla; Marco Masala; Antonio Cao; Samer S Najjar; Antonio Terracciano; Timur Nedorezov; Alexei Sharov; Alan B Zonderman; Gonçalo R Abecasis; Paul Costa; Edward Lakatta; David Schlessinger
Journal:  PLoS Genet       Date:  2006-07-10       Impact factor: 5.917

10.  Variation in FTO contributes to childhood obesity and severe adult obesity.

Authors:  Christian Dina; David Meyre; Sophie Gallina; Emmanuelle Durand; Antje Körner; Peter Jacobson; Lena M S Carlsson; Wieland Kiess; Vincent Vatin; Cecile Lecoeur; Jérome Delplanque; Emmanuel Vaillant; François Pattou; Juan Ruiz; Jacques Weill; Claire Levy-Marchal; Fritz Horber; Natascha Potoczna; Serge Hercberg; Catherine Le Stunff; Pierre Bougnères; Peter Kovacs; Michel Marre; Beverley Balkau; Stéphane Cauchi; Jean-Claude Chèvre; Philippe Froguel
Journal:  Nat Genet       Date:  2007-05-13       Impact factor: 38.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.