Literature DB >> 1967901

Three genes for enzymes of the pyruvate dehydrogenase complex map to human chromosomes 3, 7, and X.

S Olson1, B J Song, T L Huh, Y T Chi, R L Veech, O W McBride.   

Abstract

The genes for three proteins of the pyruvate dehydrogenase (PDH) complex have been assigned to human chromosomes by Southern analysis of a panel of human-rodent somatic cell hybrid DNAs with cDNA probes for these genes. PDH-E1 alpha has been localized on human chromosome 3p13-q23. The assignments of lipoamide dehydrogenase(E3) and PDH-E1 alpha [corrected] to chromosomes 7 and Xp, respectively, have been confirmed. Restrictive-fragment-length polymorphisms have been identified with E3, which will permit further localization of this gene by genetic linkage analysis.

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Year:  1990        PMID： 1967901      PMCID： PMC1684992     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  35 in total

1.  Defective gene in lactic acidosis: abnormal pyruvate dehydrogenase E1 alpha-subunit caused by a frame shift.

Authors:  H Endo; K Hasegawa; K Narisawa; K Tada; Y Kagawa; S Ohta
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

2.  Biochemical study in 28 children with lactic acidosis, in relation to Leigh's encephalomyelopathy.

Authors:  S Miyabayashi; T Ito; K Narisawa; K Iinuma; K Tada
Journal:  Eur J Pediatr       Date:  1985-03       Impact factor: 3.183

3.  X-chromosome localization of the functional gene for the E1 alpha subunit of the human pyruvate dehydrogenase complex.

Authors:  R M Brown; H H Dahl; G K Brown
Journal:  Genomics       Date:  1989-02       Impact factor: 5.736

4.  Human gene mapping 9.5. Update to the Ninth International Workshop on Human Gene Mapping. New Haven Conference, August 1988.

Authors: 
Journal:  Cytogenet Cell Genet       Date:  1988

5.  alpha-Ketoacid dehydrogenase complexes and respiratory fuel utilisation in diabetes.

Authors:  P J Randle
Journal:  Diabetologia       Date:  1985-08       Impact factor: 10.122

6.  Chromosomal localization of DBL oncogene sequences.

Authors:  S R Tronick; O W McBride; N C Popescu; A Eva
Journal:  Genomics       Date:  1989-10       Impact factor: 5.736

7.  Pyruvate dehydrogenase subcomplex with lipoamide dehydrogenase deficiency in a patient with lactic acidosis and branched chain ketoaciduria.

Authors:  S Matuda; A Kitano; Y Sakaguchi; M Yoshino; T Saheki
Journal:  Clin Chim Acta       Date:  1984-06-27       Impact factor: 3.786

8.  Regional chromosomal localization of N-ras, K-ras-1, K-ras-2 and myb oncogenes in human cells.

Authors:  O W McBride; D C Swan; S R Tronick; R Gol; D Klimanis; D E Moore; S A Aaronson
Journal:  Nucleic Acids Res       Date:  1983-12-10       Impact factor: 16.971

9.  Heterogeneous expression of protein and mRNA in pyruvate dehydrogenase deficiency.

Authors:  I D Wexler; D S Kerr; L Ho; M M Lusk; R A Pepin; A A Javed; J E Mole; B W Jesse; T J Thekkumkara; G Pons
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Gene for lipoamide dehydrogenase maps to human chromosome 7.

Authors:  G Otulakowski; B H Robinson; H F Willard
Journal:  Somat Cell Mol Genet       Date:  1988-07
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  3 in total

1.  Biochemical and molecular analysis of an X-linked case of Leigh syndrome associated with thiamin-responsive pyruvate dehydrogenase deficiency.

Authors:  E Naito; M Ito; I Yokota; T Saijo; J Matsuda; H Osaka; S Kimura; Y Kuroda
Journal:  J Inherit Metab Dis       Date:  1997-08       Impact factor: 4.982

2.  Mutation of E1 alpha gene in a female patient with pyruvate dehydrogenase deficiency due to rapid degradation of E1 protein.

Authors:  M Ito; A H Huq; E Naito; T Saijo; E Takeda; Y Kuroda
Journal:  J Inherit Metab Dis       Date:  1992       Impact factor: 4.982

3.  Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C.

Authors:  M A Papathanasiou; N C Kerr; J H Robbins; O W McBride; I Alamo; S F Barrett; I D Hickson; A J Fornace
Journal:  Mol Cell Biol       Date:  1991-02       Impact factor: 4.272
  3 in total

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