| Literature DB >> 19678962 |
Yia-Ping Liu1, Yu-Lung Lin, Chia-Hsin Chuang, Yu-Cheng Kao, Shang-Tang Chang, Che-Se Tung.
Abstract
The study examined the effects of a norepinephrine transporter (NET) inhibitor reboxetine (RBX) on an attentional performance test. Adult SD rats trained with five-choice serial reaction time task (5-CSRTT) were administered with RBX (0, 3.0 and 10 mg/kg) in the testing day. Alpha-1 adrenergic receptor antagonist PRA and alpha-2 adrenergic receptor antagonist RX821002 were used to clarify the RBX effect. Results revealed that rat received RBX at 10 mg/kg had an increase in the percentage of the correct response and decreases in the numbers of premature response. Alpha-1 adrenergic receptor antagonist Prazosin (PRA) at 0.1 mg/kg reversed the RBX augmented correct responding rate. However, alpha-2 adrenergic receptor antagonist RX821002 at 0.05 and 0.1 mg/kg dose dependently reversed the RBX reduced impulsive responding. Our results suggested that RBX as a norepinephrine transporter inhibitor can be beneficial in both attentional accuracy and response control and alpha-1 and alpha-2 adrenergic receptors might be involved differently.Entities:
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Year: 2009 PMID： 19678962 PMCID： PMC2739512 DOI： 10.1186/1423-0127-16-72
Source DB: PubMed Journal: J Biomed Sci ISSN： 1021-7770 Impact factor: 8.410