Literature DB >> 196762

The early region of SV40 DNA may have more than one gene.

B Thimmappaya, S M Weissman.   

Abstract

The nucleotide sequence of 70 base pairs (bp) around 0.545 map units (Alu I C and B junction) of the genome from the single Eco RI cleavage site within SV40 DNA is presented. The mRNA transcribed from the early strand template from this stretch contains two copies of the nonsense triplet UAA in each of the three reading frames. Thus at least 25% of the early region of SV40 DNA does not code for the SV40 "A" protein, and the viral contribution to events in the lytic cycle and transformation may be more complex than is generally appreciated.

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Year:  1977        PMID： 196762     DOI： 10.1016/0092-8674(77)90295-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  11 in total

1.  Nucleotide sequence analysis of viable deletion mutants lacking segments of the simian virus 40 genome coding for small t antigen.

Authors:  B Thimmappaya; T Shenk
Journal:  J Virol       Date:  1979-06       Impact factor: 5.103

2.  Characterization of two SV40 early mRNAs and evidence for a nuclear "prespliced" RNA species.

Authors:  E May; M Kress; P May
Journal:  Nucleic Acids Res       Date:  1978-09       Impact factor: 16.971

3.  Nucleotide sequence of the BK virus DNA segment encoding small t antigen.

Authors:  R Dhar; I Seif; G Khoury
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

4.  Common methionine-tryptic peptides near the amino-terminal end of primate papovavirus tumor antigens.

Authors:  D T Simmons; M A Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

5.  Spliced early mRNAs of simian virus 40.

Authors:  A J Berk; P A Sharp
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

6.  Role of the simian virus 40 gene A product in regulation of DNA synthesis in transformed cells.

Authors:  J S Butel; H R Soule
Journal:  J Virol       Date:  1978-06       Impact factor: 5.103

7.  Organization and expression of early genes of simian virus 40.

Authors:  L V Crawford; C N Cole; A E Smith; E Paucha; P Tegtmeyer; K Rundell; P Berg
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

8.  Large and small tumor antigens from simian virus 40 have identical amino termini mapping at 0.65 map units.

Authors:  E Paucha; A Mellor; R Harvey; A E Smith; R M Hewick; M D Waterfield
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

9.  Nucleotide sequence of the simian virus 40 small-t gene.

Authors:  G Volckaert; A Van de Voorde; W Fiers
Journal:  Proc Natl Acad Sci U S A       Date:  1978-05       Impact factor: 11.205

10.  Cell-free synthesis of simian virus 40 T-antigens.

Authors:  E Paucha; R Harvey; A E Smith
Journal:  J Virol       Date:  1978-10       Impact factor: 5.103
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