| Literature DB >> 1967425 |
W F Hendry1, L Hughes, G Scammell, J P Pryor, T B Hargreave.
Abstract
43 subfertile men with circulating antibodies to spermatozoa entered a double-blind crossover trial and received soluble prednisolone (20 mg twice daily on days 1-10 of the female partner's menstrual cycle, followed by 5 mg on days 11 and 12) or matching placebo tablets for 9 months each. 9 pregnancies were produced by men during prednisolone treatment, compared with 2 by men randomised to placebo (although only 1 was actually taking the placebo). No serious complications were produced, although 60% of those receiving prednisolone experienced mild side-effects.Entities:
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Year: 1990 PMID： 1967425 DOI： 10.1016/0140-6736(90)90548-j
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321