AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged > or = 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.
Authors: D Williams Parsons; Tian-Li Wang; Yardena Samuels; Alberto Bardelli; Jordan M Cummins; Laura DeLong; Natalie Silliman; Janine Ptak; Steve Szabo; James K V Willson; Sanford Markowitz; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Victor E Velculescu Journal: Nature Date: 2005-08-11 Impact factor: 49.962
Authors: Christopher A Haiman; Daniel O Stram; Iona Cheng; Elena E Giorgi; Loreall Pooler; Kathryn Penney; Loïc Le Marchand; Brian E Henderson; Matthew L Freedman Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-05 Impact factor: 4.254
Authors: J Abubaker; P Bavi; S Al-Harbi; M Ibrahim; A K Siraj; N Al-Sanea; A Abduljabbar; L H Ashari; S Alhomoud; F Al-Dayel; S Uddin; K S Al-Kuraya Journal: Oncogene Date: 2008-01-14 Impact factor: 9.867