BACKGROUND: Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC. METHODS: Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half-life (Tg[t(1/2)]) was estimated in a 1-compartment model. A simplified 2-point formula (24 and 120 hours) was also used. RESULTS: The mean Tg(t(1/2)) was 28.53 to 30.22 hours in 1-compartment model and 27.39 hours when estimated by a simplified formula. A strong inter-methods relationship was found (p < .001). CONCLUSIONS: A reliable Tg(t(1/2)) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively).
BACKGROUND: Knowing the postsurgery thyroglobulin (Tg) kinetic would enable its rationale for use in patients with differentiated thyroid cancer (DTC). Heterogeneous results were previously reported, then we aimed to evaluate the postsurgery Tg kinetic in a large group of patients with DTC. METHODS: Enrolled were 96 patients with DTC. Serum Tg was measured first at 5 minutes, then at 24, 48, 72, 96, and 120 hours after thyroidectomy. The Tg half-life (Tg[t(1/2)]) was estimated in a 1-compartment model. A simplified 2-point formula (24 and 120 hours) was also used. RESULTS: The mean Tg(t(1/2)) was 28.53 to 30.22 hours in 1-compartment model and 27.39 hours when estimated by a simplified formula. A strong inter-methods relationship was found (p < .001). CONCLUSIONS: A reliable Tg(t(1/2)) estimation could be obtained by a simplified formula requiring only 2 postsurgery Tg measurements (24 and 120 hours, respectively).
Authors: Bryan R Haugen; Erik K Alexander; Keith C Bible; Gerard M Doherty; Susan J Mandel; Yuri E Nikiforov; Furio Pacini; Gregory W Randolph; Anna M Sawka; Martin Schlumberger; Kathryn G Schuff; Steven I Sherman; Julie Ann Sosa; David L Steward; R Michael Tuttle; Leonard Wartofsky Journal: Thyroid Date: 2016-01 Impact factor: 6.568
Authors: Denise P Momesso; Fernanda Vaisman; Samantha P Yang; Daniel A Bulzico; Rossana Corbo; Mario Vaisman; R Michael Tuttle Journal: J Clin Endocrinol Metab Date: 2016-03-29 Impact factor: 5.958
Authors: Hee Kyung Kim; Jee Hee Yoon; Jin Seong Cho; Seong Young Kwon; Su Woong Yoo; Ho-Cheol Kang Journal: Korean J Intern Med Date: 2019-07-29 Impact factor: 2.884