| Literature DB >> 19672890 |
Abstract
Animal models for HIV research have been indispensible in fulfilling Koch's postulate and in exploring issues of viral infectivity and pathogenesis, sequence divergence, route(s) of acquisition, tissue distribution and tropism, immunogenicity and protection capacity of vaccine candidates, escape from adaptive immunity, and more. Did they fail to predict the efficacy of T-cell vaccines in humans? This article summarizes progress and status of models to inform and complement clinical work.Entities:
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Year: 2009 PMID: 19672890 PMCID: PMC2866064 DOI: 10.1002/eji.200939576
Source DB: PubMed Journal: Eur J Immunol ISSN: 0014-2980 Impact factor: 5.532