AIM: 7-Ketocholesterol concentrations can be measured in a blood sample; however, the relationship between blood 7-ketocholesterol concentrations and atherosclerotic disease is not well-known. The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis. METHODS: One hundred and thirty-nine subjects with coronary artery disease (CAD, subjects with stable angina pectoris or acute myocardial infarction) and 43 subjects with normal coronary arteries were enrolled in the study. s-7KCHO was measured using gas chromatography mass spectrometry. RESULTS: s-7KCHO was significantly higher in subjects with CAD than in those with normal coronary arteries (normal coronary artery: 19.0+/-11.3 ng/mL, CAD: 32.4+/-23.1 ng/mL, p<0.01). Furthermore, patients with multiple vessel disease had significantly higher s-7KCHO than those with single vessel disease. Multivariate analysis revealed that s-7KCHO was an independent variable for CAD (p<0.01). In CAD subjects, the presence of acute myocardial infarction, number of affected vessels, and high sensitive C-reactive protein concentrations strongly correlated with s-7KCHO (p<0.01, <0.05, <0.05, respectively). CONCLUSION: These results indicate that high s-7KCHO is closely associated with the progression of coronary atherosclerosis and inflammation.
AIM: 7-Ketocholesterol concentrations can be measured in a blood sample; however, the relationship between blood 7-ketocholesterol concentrations and atherosclerotic disease is not well-known. The aim of this study was to clarify the clinical significance of serum 7-ketocholesterol concentrations (s-7KCHO) in the progression of coronary atherosclerosis. METHODS: One hundred and thirty-nine subjects with coronary artery disease (CAD, subjects with stable angina pectoris or acute myocardial infarction) and 43 subjects with normal coronary arteries were enrolled in the study. s-7KCHO was measured using gas chromatography mass spectrometry. RESULTS: s-7KCHO was significantly higher in subjects with CAD than in those with normal coronary arteries (normal coronary artery: 19.0+/-11.3 ng/mL, CAD: 32.4+/-23.1 ng/mL, p<0.01). Furthermore, patients with multiple vessel disease had significantly higher s-7KCHO than those with single vessel disease. Multivariate analysis revealed that s-7KCHO was an independent variable for CAD (p<0.01). In CAD subjects, the presence of acute myocardial infarction, number of affected vessels, and high sensitive C-reactive protein concentrations strongly correlated with s-7KCHO (p<0.01, <0.05, <0.05, respectively). CONCLUSION: These results indicate that high s-7KCHO is closely associated with the progression of coronary atherosclerosis and inflammation.
Authors: Tijana Mitić; Steven Shave; Nina Semjonous; Iain McNae; Diego F Cobice; Gareth G Lavery; Scott P Webster; Patrick W F Hadoke; Brian R Walker; Ruth Andrew Journal: Biochem Pharmacol Date: 2013-02-13 Impact factor: 5.858
Authors: Amelia Anderson; Angielyn Campo; Elena Fulton; Anne Corwin; W Gray Jerome; Matthew S O'Connor Journal: Redox Biol Date: 2019-11-14 Impact factor: 11.799