Literature DB >> 19671629

A little bit of sugar makes polycomb better.

Yuri B Schwartz1, Vincenzo Pirrotta.   

Abstract

Transcriptional repression by Polycomb group (PcG) proteins is now sweetened by the discovery of the essential role of O-GlcNAc glycosylation in the process. PcG protein polyhomeotic may be the key target, but alternative or additional functions including repression of transcription through glycosylation of the C-terminal domain of RNA polymerase II are also possible.

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Year:  2009        PMID: 19671629     DOI: 10.1093/jmcb/mjp008

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN: 1759-4685            Impact factor:   6.216


  2 in total

1.  The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways.

Authors:  Natasha E Zachara; Henrik Molina; Ker Yi Wong; Akhilesh Pandey; Gerald W Hart
Journal:  Amino Acids       Date:  2010-07-31       Impact factor: 3.520

2.  Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription.

Authors:  David F Allison; J Jacob Wamsley; Manish Kumar; Duo Li; Lisa G Gray; Gerald W Hart; David R Jones; Marty W Mayo
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-01       Impact factor: 11.205

  2 in total

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