Literature DB >> 19670162

Flavonol glycosides from the south African medicinal plant Sutherlandia frutescens.

Xiang Fu1, Xing-Cong Li, Yan-Hong Wang, Bharathi Avula, Troy J Smillie, Wilfred Mabusela, James Syce, Quinton Johnson, William Folk, Ikhlas A Khan.   

Abstract

Phytochemical investigation of the leaves of Sutherlandia frutescens led to the isolation of four new 3-hydroxy-3-methylglutaroyl-containing flavonol glycosides, sutherlandins A-D ( 1- 4). Their structures were elucidated by chemical and spectroscopic methods as quercetin 3- O- beta- D-xylopyranosyl(1 --> 2)-[6- O-(3-hydroxy-3-methylglutaroyl)]- beta- D-glucopyranoside ( 1), quercetin 3- O- beta- D-apiofuranosyl(1 --> 2)-[6- O-(3-hydroxy-3-methylglutaroyl)]- beta- D-glucopyranoside ( 2), kaempferol 3- O- beta- D-xylopyranosyl(1 --> 2)-[6- O-(3-hydroxy-3-methylglutaroyl)]- beta- D-glucopyranoside ( 3), and kaempferol 3- O- beta- D-apiofuranosyl(1 --> 2)-[6- O-(3-hydroxy-3-methylglutaroyl)]- beta- D-glucopyranoside ( 4). Georg Thieme Verlag KG Stuttgart . New York.

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Year:  2009        PMID: 19670162     DOI: 10.1055/s-0029-1186030

Source DB:  PubMed          Journal:  Planta Med        ISSN: 0032-0943            Impact factor:   3.352


  13 in total

1.  Sutherlandia frutescens: the meeting of science and traditional knowledge.

Authors:  Oluwaseyi M Aboyade; Gustav Styger; Diana Gibson; Gail Hughes
Journal:  J Altern Complement Med       Date:  2013-07-09       Impact factor: 2.579

2.  Isolation of sutherlandins A, B, C and D from Sutherlandia frutescens (L.) R. Br. by counter-current chromatography using spiral tubing support rotors.

Authors:  Cuiping Chen; William R Folk; Rodrigo Lazo-Portugal; Thomas M Finn; Martha Knight
Journal:  J Chromatogr A       Date:  2017-05-22       Impact factor: 4.759

3.  Isolation of Sutherlandioside B from Sutherlandia frutescens by Spiral Countercurrent Chromatography.

Authors:  Korey J Brownstein; George E Rottinghaus; Martha Knight; Yoichiro Ito; William Folk
Journal:  J Liq Chromatogr Relat Technol       Date:  2015       Impact factor: 1.312

4.  Immuno-stimulatory activity of a polysaccharide-enriched fraction of Sutherlandia frutescens occurs by the toll-like receptor-4 signaling pathway.

Authors:  Wei Lei; Jimmy D Browning; Peggy A Eichen; Chi-Hua Lu; Valeri V Mossine; George E Rottinghaus; William R Folk; Grace Y Sun; Dennis B Lubahn; Kevin L Fritsche
Journal:  J Ethnopharmacol       Date:  2015-06-18       Impact factor: 4.360

5.  Effect of short term and chronic administration of Sutherlandia frutescens on pharmacokinetics of nevirapine in rats.

Authors:  Mukul Minocha; Nanda K Mandava; Deep Kwatra; Dhananjay Pal; William R Folk; Ravinder Earla; Ashim K Mitra
Journal:  Int J Pharm       Date:  2011-04-23       Impact factor: 5.875

6.  Quantitative determination of flavonoids and cycloartanol glycosides from aerial parts of Sutherlandia frutescens (L.) R. BR. by using LC-UV/ELSD methods and confirmation by using LC-MS method.

Authors:  Bharathi Avula; Yan-Hong Wang; Troy J Smillie; Xiang Fu; Xing Cong Li; Wilfred Mabusela; James Syce; Quinton Johnson; William Folk; Ikhlas A Khan
Journal:  J Pharm Biomed Anal       Date:  2010-01-15       Impact factor: 3.935

7.  Unveiling the anti-inflammatory activity of Sutherlandia frutescens using murine macrophages.

Authors:  Wei Lei; Jimmy D Browning; Peggy A Eichen; Korey J Brownstein; William R Folk; Grace Y Sun; Dennis B Lubahn; George E Rottinghaus; Kevin L Fritsche
Journal:  Int Immunopharmacol       Date:  2015-11-12       Impact factor: 4.932

8.  Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir.

Authors:  Adrienne C Müller; Michael F Skinner; Isadore Kanfer
Journal:  Evid Based Complement Alternat Med       Date:  2013-12-12       Impact factor: 2.629

9.  Sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells.

Authors:  Jinghua Jiang; Dennis Y Chuang; Yijia Zong; Jayleenkumar Patel; Korey Brownstein; Wei Lei; Chi-Hua Lu; Agnes Simonyi; Zezong Gu; Jiankun Cui; George E Rottinghaus; Kevin L Fritsche; Dennis B Lubahn; William R Folk; Grace Y Sun
Journal:  PLoS One       Date:  2014-02-25       Impact factor: 3.240

10.  Antioxidant potential of Sutherlandia frutescens and its protective effects against oxidative stress in various cell cultures.

Authors:  Shakila Tobwala; Weili Fan; Connor J Hines; William R Folk; Nuran Ercal
Journal:  BMC Complement Altern Med       Date:  2014-07-29       Impact factor: 3.659

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