Literature DB >> 19670160

Ganoderic acids from Ganoderma lucidum: inhibitory activity of osteoclastic differentiation and structural criteria.

Jie Liu1, Jun Shiono, Kuniyoshi Shimizu, Ryuichiro Kondo.   

Abstract

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases. Ganoderma lucidum is known for medicinal effects such as anti-inflammatory and anti-bone resorption activities. In this study, we investigated the inhibitory effects of ganoderic acids isolated from G. lucidum on osteoclastic differentiation using RAW264 cells in vitro. A carbonyl in C7 is essential to elicit the inhibition of osteoclast differentiation. Georg Thieme Verlag KG Stuttgart . New York.

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Year:  2009        PMID： 19670160     DOI： 10.1055/s-0029-1186035

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  3 in total

1.  Endoplasmic reticulum stress, autophagic and apoptotic cell death, and immune activation by a natural triterpenoid in human prostate cancer cells.

Authors:  Benjamin M Johnson; Faisal F Y Radwan; Azim Hossain; Bently P Doonan; Jessica D Hathaway-Schrader; Jason M God; Christina V Voelkel-Johnson; Narendra L Banik; Sakamuri V Reddy; Azizul Haque
Journal:  J Cell Biochem       Date:  2018-10-30       Impact factor: 4.429

2.  Deep insight into the Ganoderma lucidum by comprehensive analysis of its transcriptome.

Authors:  Guo-Jun Yu; Man Wang; Jie Huang; Ya-Lin Yin; Yi-Jie Chen; Shuai Jiang; Yan-Xia Jin; Xian-Qing Lan; Barry Hon Cheung Wong; Yi Liang; Hui Sun
Journal:  PLoS One       Date:  2012-08-27       Impact factor: 3.240

3.  Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms.

Authors:  Jie Liu; Kuniyoshi Shimizu; Akinobu Tanaka; Wakako Shinobu; Koichiro Ohnuki; Takanori Nakamura; Ryuichiro Kondo
Journal:  Sci Rep       Date:  2012-11-30       Impact factor: 4.379
  3 in total

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