| Literature DB >> 19669856 |
Renata Rodrigues de Carvalho1, Fernanda de Paula Eduardo, Karen Müller Ramalho, José Leopoldo Ferreira Antunes, Letícia Mello Bezinelli, Marina Helena Cury Gallottini de Magalhães, Tatiana Pegoretti, Patrícia Moreira de Freitas, Carlos de Paula Eduardo.
Abstract
Alternative treatment for recurrent labial infection by herpes simplex virus (HSV) have been considered. The aim of this study was to evaluate the effectiveness of laser phototherapy in prevention and reduction of severity of labial manifestations of herpes labialis virus. Seventy-one patients, divided into experimental (n = 41) and control (n = 30) groups were followed up for 16 months. Patients in the control group were treated topically with aciclovir and patients in the experimental group were subjected to laser phototherapy (one session per week, 10 weeks): 780 nm, 60 mW, 3.0 J/cm(2) or 4.5 J/cm(2) on healthy (no HSV-1 infection) and affected (with HSV-1 infection) tissues. Patients in the experimental group presented a significant decrease in dimension of herpes labialis lesions (P = 0.013) and inflammatory edema (P = 0.031). The reduction in pain level (P = 0.051) and monthly recurrences (P = 0.076) did not reach statistical significance. This study represents an in vivo indication that this treatment should be further considered as an effective alternative to therapeutic regimens for herpes labialis lesions.Entities:
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Year: 2009 PMID： 19669856 DOI： 10.1007/s10103-009-0717-9
Source DB: PubMed Journal: Lasers Med Sci ISSN： 0268-8921 Impact factor: 3.161