| Literature DB >> 19669341 |
Hakan Akın1, Mustafa Deniz, Veysel Tahan, Güray Can, Alla Eldeen Kedrah, Ciğdem Celikel, Nurdan Tözün, Neşe Imeryüz.
Abstract
We could not reproduce the model described by Lieber et al for nonalcoholic steatohepatitis model in rats. In our trial the high fat liquid diet group of rats gained nearly 100 g or less weight compared to the mean weight gain stated in the original article. However, the fasting glucose level was statistically higher in this group as compared to the chow diet group. Some pathological abnormalities in the duodenum and jejunum samples were observed in the high fat liquid diet group. We do not know the exact reason for these changes. Overall, our study results arose some suspicions about the reproducibility of the model. Furthermore, to the best of our knowledge, no study using the proposed model has been published so far.Entities:
Year: 2007 PMID： 19669341 PMCID： PMC2717546 DOI： 10.1007/s12072-007-9028-z
Source DB: PubMed Journal: Hepatol Int ISSN： 1936-0533 Impact factor: 6.047