Literature DB >> 19668856

Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-zeta inhibitors and potential therapeutics for psychostimulant abuse.

Langtian Yuan1, Jin-Soo Seo, Nam Sook Kang, Shahar Keinan, Sarah E Steele, Gregory A Michelotti, William C Wetsel, David N Beratan, Young-Dae Gong, Tong H Lee, Jiyong Hong.   

Abstract

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-zeta inhibitors.

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Year:  2009        PMID： 19668856      PMCID： PMC2747283          DOI： 10.1039/b903036k

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  26 in total

1.  Distribution of protein kinase Mzeta and the complete protein kinase C isoform family in rat brain.

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2.  Solid-phase synthesis of 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via selective, reagent-based cyclization of acyldithiocarbazate resins.

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Journal:  J Comb Chem       Date:  2005 Nov-Dec

Review 3.  Targeting the protein kinase C family: are we there yet?

Authors:  Helen J Mackay; Christopher J Twelves
Journal:  Nat Rev Cancer       Date:  2007-07       Impact factor: 60.716

Review 4.  Protein kinase C: structure, function, and regulation.

Authors:  A C Newton
Journal:  J Biol Chem       Date:  1995-12-01       Impact factor: 5.157

5.  Chelerythrine is a potent and specific inhibitor of protein kinase C.

Authors:  J M Herbert; J M Augereau; J Gleye; J P Maffrand
Journal:  Biochem Biophys Res Commun       Date:  1990-11-15       Impact factor: 3.575

6.  Solid-phase synthesis of 5-amino-1-(substituted thiocarbamoyl)pyrazole and 1,2,4-triazole derivatives via dithiocarbazate linker.

Authors:  Jong Yeon Hwang; Hyung-Sub Choi; Duck-Hyung Lee; Sung-Eun Yoo; Young-Dae Gong
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7.  Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.

Authors:  Albrecht Messerschmidt; Sofia Macieira; Milko Velarde; Mathias Bädeker; Christian Benda; Anja Jestel; Hans Brandstetter; Torsten Neuefeind; Michael Blaesse
Journal:  J Mol Biol       Date:  2005-09-30       Impact factor: 5.469

8.  Solid-phase synthesis of the 2-aminobenzoxazole library using thioether linkage as the safety-catch linker.

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Journal:  J Comb Chem       Date:  2006 May-Jun

Review 9.  Rasagiline promotes regeneration of substantia nigra dopaminergic neurons in post-MPTP-induced Parkinsonism via activation of tyrosine kinase receptor signaling pathway.

Authors:  Silvia A Mandel; Yotam Sagi; Tamar Amit
Journal:  Neurochem Res       Date:  2007-08-16       Impact factor: 3.996

Review 10.  Removing pathogenic memories: a neurobiology of psychotherapy.

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  4 in total

1.  Novel atypical PKC inhibitors prevent vascular endothelial growth factor-induced blood-retinal barrier dysfunction.

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2.  Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation.

Authors:  Colin L Willis; Diana S Meske; Thomas P Davis
Journal:  J Cereb Blood Flow Metab       Date:  2010-08-11       Impact factor: 6.200

3.  PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.

Authors:  Sheng Yao; Alix Bee; Daniel Brewer; Andrew Dodson; Carol Beesley; Youqiang Ke; Laurence Ambroisine; Gabrielle Fisher; Heinrich Møller; Tim Dickinson; Patricia Gerard; Lu-Yu Lian; Janet Risk; Brian Lane; Paul Smith; Victor Reuter; Daniel Berney; Christine Gosden; Peter Scardino; Jack Cuzick; Mustafa B A Djamgoz; Colin Cooper; Christopher S Foster
Journal:  Genes Cancer       Date:  2010-05

Review 4.  Targeting protein kinase C subtypes in pancreatic cancer.

Authors:  Peter Storz
Journal:  Expert Rev Anticancer Ther       Date:  2015-01-20       Impact factor: 4.512
  4 in total

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