BACKGROUND: Celiac disease (CD) can be associated with a variety of extraintestinal manifestations, including neurological diseases. A new neurological correlation has been found between CD and sensorineural hearing loss (SNHL). OBJECTIVE: To verify the association between SNHL and CD, and to establish whether the neurological hearing impairment in CD is related to nonorgan-specific and antineuronal antibodies, as well as the presence of autoimmune disorders. METHODS: A sample of 59 consecutive biopsy- and serologically proven CD patients were studied. Among CD patients, 11 were newly diagnosed and 48 were on a gluten-free diet. Hearing function was assessed by audiometric analysis in all CD patients as well as in 59 age- and sex-matched controls. Patients were tested for a panel of immune markers including nonorgan-specific autoantibodies and antineuronal antibodies. RESULTS: SNHL was detected in five CD patients (8.5%) and in two controls (3.4%). In one patient, the SNHL was bilateral, whereas the remaining four had a monolateral impairment. The prevalence of SNHL was not significantly different between CD patients and controls. At least one of the antibodies tested for was positive in two of the five CD patients with SNHL and in 12 of the 54 CD patients without SNHL. Antineuronal antibodies to central nervous system antigens were consistently negative in the five CD patients with SNHL. Only one of the five CD patients with SNHL had Hashimoto thyroiditis. CONCLUSIONS: SNHL and CD occur coincidentally. Hearing function should be assessed only in CD patients with clinical signs of hearing deficiency.
BACKGROUND:Celiac disease (CD) can be associated with a variety of extraintestinal manifestations, including neurological diseases. A new neurological correlation has been found between CD and sensorineural hearing loss (SNHL). OBJECTIVE: To verify the association between SNHL and CD, and to establish whether the neurological hearing impairment in CD is related to nonorgan-specific and antineuronal antibodies, as well as the presence of autoimmune disorders. METHODS: A sample of 59 consecutive biopsy- and serologically proven CDpatients were studied. Among CDpatients, 11 were newly diagnosed and 48 were on a gluten-free diet. Hearing function was assessed by audiometric analysis in all CDpatients as well as in 59 age- and sex-matched controls. Patients were tested for a panel of immune markers including nonorgan-specific autoantibodies and antineuronal antibodies. RESULTS: SNHL was detected in five CDpatients (8.5%) and in two controls (3.4%). In one patient, the SNHL was bilateral, whereas the remaining four had a monolateral impairment. The prevalence of SNHL was not significantly different between CDpatients and controls. At least one of the antibodies tested for was positive in two of the five CDpatients with SNHL and in 12 of the 54 CDpatients without SNHL. Antineuronal antibodies to central nervous system antigens were consistently negative in the five CDpatients with SNHL. Only one of the five CDpatients with SNHL had Hashimoto thyroiditis. CONCLUSIONS: SNHL and CD occur coincidentally. Hearing function should be assessed only in CDpatients with clinical signs of hearing deficiency.
Authors: U Volta; S Bellentani; F B Bianchi; G Brandi; L De Franceschi; L Miglioli; A Granito; F Balli; C Tiribelli Journal: Dig Dis Sci Date: 2001-07 Impact factor: 3.199
Authors: Umberto Volta; Luis Rodrigo; Alessandro Granito; Nunzio Petrolini; Paolo Muratori; Luigi Muratori; Antonio Linares; Lorenza Veronesi; Dolores Fuentes; Daniela Zauli; Francesco B Bianchi Journal: Am J Gastroenterol Date: 2002-10 Impact factor: 10.864
Authors: Armin Alaedini; Peter H R Green; Howard W Sander; Arthur P Hays; Eugenia T Gamboa; Alessio Fasano; Michelle Sonnenberg; Linda D Lewis; Norman Latov Journal: J Neuroimmunol Date: 2002-06 Impact factor: 3.478
Authors: Paolo Muratori; Alessandro Granito; Georgios Pappas; Luigi Muratori; Marco Lenzi; Francesco B Bianchi Journal: Mol Aspects Med Date: 2007-10-24