Literature DB >> 19666230

T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.

Wendy S Garrett1, Laurie H Glimcher.   

Abstract

Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig. 1]. The TRUC (T-bet-/- RAG2-/- ulcerative colitis) model is discussed in the broader context of the adaptive and innate immune mechanisms that regulate host-commensal relationships within the intestine.

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Year:  2009        PMID： 19666230      PMCID： PMC2836906          DOI： 10.1016/j.cyto.2009.07.007

Source DB:  PubMed          Journal:  Cytokine        ISSN： 1043-4666            Impact factor:   3.861


  43 in total

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4.  MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice.

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