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Literature DB >> 19666142

The quasispecies nature and biological implications of the hepatitis C virus.

Abstract

Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
RNA, Viral

Year: 2009 PMID： 19666142 PMCID： PMC2790008 DOI： 10.1016/j.meegid.2009.07.011

Source DB: PubMed Journal: Infect Genet Evol ISSN： 1567-1348 Impact factor: 3.342

144 in total

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6. Evolution of envelope sequences from the genital tract and peripheral blood of women infected with clade A human immunodeficiency virus type 1.

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Journal: J Virol Date: 1998-10 Impact factor: 5.103

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Review 8. The nature of interferon-alpha resistance in hepatitis C virus infection.

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9. Influence of the genetic heterogeneity of the ISDR and PePHD regions of hepatitis C virus on the response to interferon therapy in chronic hepatitis C.

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10. Validating viral quasispecies with digital organisms: a re-examination of the critical mutation rate.

Authors: Iñaki Comas; Andrés Moya; Fernando González-Candelas
Journal: BMC Evol Biol Date: 2005-01-15 Impact factor: 3.260

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4. Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma.

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7. Cross-genotypic polyclonal anti-HCV antibodies from human ascitic fluid.

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