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Literature DB >> 19665965

DNA makes RNA makes innate immunity.

Abstract

Microbial DNA in the cytosol induces production of interferon-beta (IFN-beta) and an innate immune response. Chiu et al. (2009) now implicate cytosolic DNA-dependent RNA polymerase III as the DNA sensor linking DNA release by pathogenic bacteria and viruses in the host cell cytosol to IFN-beta production and innate immunity.

Entities: Gene

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Year: 2009 PMID： 19665965 DOI： 10.1016/j.cell.2009.07.021

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

15 in total

1. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.

Authors: Pengyuan Yang; Huazhang An; Xingguang Liu; Mingyue Wen; Yuanyuan Zheng; Yaocheng Rui; Xuetao Cao
Journal: Nat Immunol Date: 2010-05-09 Impact factor: 25.606

Review 2. ADARs: viruses and innate immunity.

Authors: Charles E Samuel
Journal: Curr Top Microbiol Immunol Date: 2012 Impact factor: 4.291

Review 3. Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response.

Authors: Christian K Pfaller; Zhiqun Li; Cyril X George; Charles E Samuel
Journal: Curr Opin Immunol Date: 2011-09-15 Impact factor: 7.486

DNA makes RNA makes innate immunity.

1. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.

Review 2. ADARs: viruses and innate immunity.

Review 3. Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response.

4. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Review 5. Mitochondria in innate immune signaling.

6. Small RNAs tackle large viruses: RNA interference-based antiviral defense against DNA viruses in insects.

Review 7. RNA polymerase III and antiviral innate immune response.

8. Both TLR2 and TRIF contribute to interferon-β production during Listeria infection.

9. New insights into the mechanisms of innate immune receptor signalling in fibrosis.

10. Late multiple organ surge in interferon-regulated target genes characterizes staphylococcal enterotoxin B lethality.