| Literature DB >> 19665897 |
Bo Yang1, Jun Lin, Yong Chen, Yu Liu.
Abstract
An inclusion complex of the antimalarial artemether (ATM) in hydroxypropyl-beta-cyclodextrin (HPbetaCD) was prepared and characterized. The phase-solubility diagram for the drug showed an increase in water solubility and gave an apparent binding constant of 220 M(-1). According to (1)H NMR and 2D NMR spectroscopy (ROESY), the inclusion mode involves two CH(3) from the drug orientated in the HPbetaCD cavity. The complex was characterized by Powder X-ray diffraction and thermal analysis. In addition, the complex produces a 1.81-fold enhancement in apparent bioavailability compared to artemether.Entities:
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Year: 2009 PMID： 19665897 DOI： 10.1016/j.bmc.2009.07.060
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641