| Literature DB >> 19665894 |
Peter I Dosa1, Sonja Strah-Pleynet, Honnappa Jayakumar, Martin Casper, Marc Decaire, Yifeng Xiong, Juerg Lehmann, Karoline Choi, Katie Elwell, Amy Wong, Robert R Webb, John W Adams, Juan Ramirez, Jeremy G Richman, William Thomsen, Graeme Semple, Bradley R Teegarden.
Abstract
Potent 5-HT(2A) inverse-agonists containing phenyl-pyrazole ureas with an amino side chain were identified. Optimization of this series resulted in selective compounds that proved effective in modulating 5HT-induced amplification of ADP-stimulated human platelet aggregation.Entities:
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Year: 2009 PMID： 19665894 DOI： 10.1016/j.bmcl.2009.07.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823