BACKGROUND: Although uncontrolled asthma remains frequent, determinants of asthma control are poorly studied. OBJECTIVES: The aim was to estimate the distribution and the phenotypic characteristics of asthma control in 2 groups of subjects defined by the use of inhaled corticosteroids (ICS) in the past 12 months, in the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA). METHODS: Five hundred one adult current patients with asthma who participated in the follow-up of the EGEA study were included. Asthma control was assessed from survey questions reflecting asthma control, as defined in the 2006 Global Initiative for Asthma guidelines. The factors analyzed were age, sex, educational level, body mass index, active and passive smoking, sensitization to aeroallergens, total IgE, rhinitis, chronic cough/phlegm, and age at asthma onset. Analyses were stratified according to ICS use. RESULTS: Uncontrolled asthma was more frequent in ICS users (27.6%, 35.0%, and 37.4% with controlled, partly-controlled, and uncontrolled asthma respectively) compared with non-ICS users (60.0%, 23.9%, and 16.1%, respectively). In ICS users, chronic cough or phlegm and female sex were independently and significantly related to uncontrolled asthma. In non-ICS users, high total IgE and sensitization to molds were associated with uncontrolled asthma. Smoking and rhinitis were not associated with asthma control. CONCLUSION: Optimal asthma control remained unachieved in the majority of patients with asthma in this study. Factors associated with uncontrolled asthma were different in ICS users (chronic cough/phlegm, female sex) and non-ICS users (high total IgE and sensitization to molds).
BACKGROUND: Although uncontrolled asthma remains frequent, determinants of asthma control are poorly studied. OBJECTIVES: The aim was to estimate the distribution and the phenotypic characteristics of asthma control in 2 groups of subjects defined by the use of inhaled corticosteroids (ICS) in the past 12 months, in the Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy (EGEA). METHODS: Five hundred one adult current patients with asthma who participated in the follow-up of the EGEA study were included. Asthma control was assessed from survey questions reflecting asthma control, as defined in the 2006 Global Initiative for Asthma guidelines. The factors analyzed were age, sex, educational level, body mass index, active and passive smoking, sensitization to aeroallergens, total IgE, rhinitis, chronic cough/phlegm, and age at asthma onset. Analyses were stratified according to ICS use. RESULTS: Uncontrolled asthma was more frequent in ICS users (27.6%, 35.0%, and 37.4% with controlled, partly-controlled, and uncontrolled asthma respectively) compared with non-ICS users (60.0%, 23.9%, and 16.1%, respectively). In ICS users, chronic cough or phlegm and female sex were independently and significantly related to uncontrolled asthma. In non-ICS users, high total IgE and sensitization to molds were associated with uncontrolled asthma. Smoking and rhinitis were not associated with asthma control. CONCLUSION: Optimal asthma control remained unachieved in the majority of patients with asthma in this study. Factors associated with uncontrolled asthma were different in ICS users (chronic cough/phlegm, female sex) and non-ICS users (high total IgE and sensitization to molds).
Authors: Gwen S Skloot; Paula J Busse; Sidney S Braman; Elizabeth J Kovacs; Anne E Dixon; Carlos A Vaz Fragoso; Nicola Scichilone; Y S Prakash; Christina M Pabelick; Sameer K Mathur; Nicola A Hanania; Wendy C Moore; Peter G Gibson; Susan Zieman; Betina B Ragless Journal: Ann Am Thorac Soc Date: 2016-11
Authors: Lidwien A M Smit; Manolis Kogevinas; Josep M Antó; Emmanuelle Bouzigon; Juan Ramón González; Nicole Le Moual; Hans Kromhout; Anne-Elie Carsin; Isabelle Pin; Deborah Jarvis; Roel Vermeulen; Christer Janson; Joachim Heinrich; Ivo Gut; Mark Lathrop; Miguel A Valverde; Florence Demenais; Francine Kauffmann Journal: Respir Res Date: 2012-03-23
Authors: Bénédicte Jacquemin; Valérie Siroux; Margaux Sanchez; Anne-Elie Carsin; Tamara Schikowski; Martin Adam; Valeria Bellisario; Anna Buschka; Roberto Bono; Bert Brunekreef; Yutong Cai; Marta Cirach; Françoise Clavel-Chapelon; Christophe Declercq; Roberto de Marco; Audrey de Nazelle; Regina E Ducret-Stich; Virginia Valeria Ferretti; Margaret W Gerbase; Rebecca Hardy; Joachim Heinrich; Christer Janson; Deborah Jarvis; Zaina Al Kanaani; Dirk Keidel; Diana Kuh; Nicole Le Moual; Mark J Nieuwenhuijsen; Alessandro Marcon; Lars Modig; Isabelle Pin; Thierry Rochat; Christian Schindler; Dorothea Sugiri; Morgane Stempfelet; Sofia Temam; Ming-Yi Tsai; Raphaëlle Varraso; Danielle Vienneau; Andrea Vierkötter; Anna L Hansell; Ursula Krämer; Nicole M Probst-Hensch; Jordi Sunyer; Nino Künzli; Francine Kauffmann Journal: Environ Health Perspect Date: 2015-02-24 Impact factor: 9.031