Literature DB >> 19665475

Preparation and characterization of N-heterocyclic chitosan derivative based gels for biomedical applications.

Santosh Kumar1, Joydeep Dutta, P K Dutta.   

Abstract

The novel N-heterocyclic chitosan aerogel derivatives were prepared by reacting 79% deacetylated chitosan separately with 4-pyridinecarboxaldehyde and 2,6-pyridinedicarboxaldehyde followed by subsequent solvent exchange into acetone, filteration and lyophilization. The identity of the Schiff bases was confirmed by UV-vis absorption spectroscopy and Fourier transform infrared (FTIR) spectroscopy. The N-heterocyclic chitosan derivatives were evaluated by X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), rheological studies and biological activity. Overall, the N-heterocyclic chitosan derivative based gels open new perspectives in biomedical applications.

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Year:  2009        PMID： 19665475     DOI： 10.1016/j.ijbiomac.2009.08.002

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  8 in total

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Journal:  Int J Mol Sci       Date:  2012-05-18       Impact factor: 6.208

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4.  Synthesis and Characterization of a Minophosphonate Containing Chitosan Polymer Derivatives: Investigations of Cytotoxic Activity and in Silico Study of SARS-CoV-19.

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Journal:  Polymers (Basel)       Date:  2021-03-26       Impact factor: 4.329

Review 5.  Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy.

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Journal:  Polymers (Basel)       Date:  2022-02-27       Impact factor: 4.329

Review 6.  Design of Chitosan Sterilization Agents by a Structure Combination Strategy and Their Potential Application in Crop Protection.

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Journal:  Molecules       Date:  2021-05-28       Impact factor: 4.411

7.  Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin.

Authors:  Jingmou Yu; Xin Xie; Meirong Zheng; Ling Yu; Lei Zhang; Jianguo Zhao; Dengzhao Jiang; Xiangxin Che
Journal:  Int J Nanomedicine       Date:  2012-09-21

8.  New Chitosan Polymer Scaffold Schiff Bases as Potential Cytotoxic Activity: Synthesis, Molecular Docking, and Physiochemical Characterization.

Authors:  Ponnusamy Packialakshmi; Perumal Gobinath; Daoud Ali; Saud Alarifi; Raman Gurusamy; Akbar Idhayadhulla; Radhakrishnan Surendrakumar
Journal:  Front Chem       Date:  2022-01-17       Impact factor: 5.221
  8 in total

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