| Literature DB >> 19665385 |
Daniel Obando1, Namfon Pantarat, Rosemary Handke, Yasuko Koda, Fred Widmer, Julianne T Djordjevic, David H Ellis, Tania C Sorrell, Katrina A Jolliffe.
Abstract
A series of bis(alkylpyridinium)alkanes with a twelve carbon spacer between the positive charges was synthesised and their antifungal activity has been investigated. Compounds with 2-pentyl, 4-pentyl, 4-hexyl, 4-octyl, 4-propylbenzene, 3,4-dipentyl, 4-(5'-nonyl) and 3-methyl,4-pentyl head groups were the most potent antifungal agents with MICs in the range of 1.4-2.7 microM against reference strains of both Cryptococcus neoformans and Candida albicans.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19665385 DOI： 10.1016/j.bmc.2009.07.037
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641