Literature DB >> 19665024

Molecular immune signatures of HIV-1 vaccines in human PBMCs.

Alessandro Monaco1, Francesco M Marincola, Marianna Sabatino, Zoltan Pos, Maria Lina Tornesello, David F Stroncek, Ena Wang, George K Lewis, Franco M Buonaguro, Luigi Buonaguro.   

Abstract

The global transcriptional profile of peripheral blood mononuclear cells (PBMCs) stimulated with HIV candidate vaccine (virus-like particles, VLPs) has been evaluated in HIV-infected patients with low/high viral load compared to healthy volunteers. Baseline activation of chemokine production was observed in PBMC from HIV-infected patients and innate immune stimulation with HIV-VLPs was not blunted. The immune profile among HIV-infected patients was found to be qualitatively similar but quantitatively extremely variable. This diversity was independent of viral load and it might be dependent on individual immunogenetic traits or concurrent immunological status. This ex vivo screening strategy represents an efficient tool for guiding modifications/optimizations of vaccination strategies and understanding failures in individuals enrolled in clinical trials.

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Year:  2009        PMID： 19665024      PMCID： PMC3418664          DOI： 10.1016/j.febslet.2009.07.060

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  24 in total

1.  High-fidelity mRNA amplification for gene profiling.

Authors:  E Wang; L D Miller; G A Ohnmacht; E T Liu; F M Marincola
Journal:  Nat Biotechnol       Date:  2000-04       Impact factor: 54.908

2.  Baculovirus-derived human immunodeficiency virus type 1 virus-like particles activate dendritic cells and induce ex vivo T-cell responses.

Authors:  L Buonaguro; M L Tornesello; M Tagliamonte; R C Gallo; L X Wang; R Kamin-Lewis; S Abdelwahab; G K Lewis; F M Buonaguro
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

Review 3.  The emerging role of innate immunity in protection against HIV-1 infection.

Authors:  T Lehner; Y Wang; J Pido-Lopez; T Whittall; L A Bergmeier; K Babaahmady
Journal:  Vaccine       Date:  2007-12-17       Impact factor: 3.641

4.  Induction of systemic and mucosal cross-clade neutralizing antibodies in BALB/c mice immunized with human immunodeficiency virus type 1 clade A virus-like particles administered by different routes of inoculation.

Authors:  L Buonaguro; M L Visciano; M L Tornesello; M Tagliamonte; B Biryahwaho; F M Buonaguro
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

5.  Cluster analysis and display of genome-wide expression patterns.

Authors:  M B Eisen; P T Spellman; P O Brown; D Botstein
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-08       Impact factor: 11.205

6.  Prospective molecular profiling of melanoma metastases suggests classifiers of immune responsiveness.

Authors:  Ena Wang; Lance D Miller; Galen A Ohnmacht; Simone Mocellin; Ainhoa Perez-Diez; David Petersen; Yingdong Zhao; Richard Simon; John I Powell; Esther Asaki; H Richard Alexander; Paul H Duray; Meenhard Herlyn; Nicholas P Restifo; Edison T Liu; Steven A Rosenberg; Francesco M Marincola
Journal:  Cancer Res       Date:  2002-07-01       Impact factor: 12.701

7.  DNA-VLP prime-boost intra-nasal immunization induces cellular and humoral anti-HIV-1 systemic and mucosal immunity with cross-clade neutralizing activity.

Authors:  L Buonaguro; C Devito; M L Tornesello; U Schröder; B Wahren; J Hinkula; F M Buonaguro
Journal:  Vaccine       Date:  2007-06-11       Impact factor: 3.641

8.  RNA amplification for successful gene profiling analysis.

Authors:  Ena Wang
Journal:  J Transl Med       Date:  2005-07-25       Impact factor: 5.531

9.  Polarized monocyte response to cytokine stimulation.

Authors:  Dirk Nagorsen; Sara Deola; Kina Smith; Ena Wang; Vladia Monsurro; Paola Zanovello; Francesco M Marincola; Monica C Panelli
Journal:  Genome Biol       Date:  2005-01-21       Impact factor: 13.583

10.  Selection and validation of endogenous reference genes using a high throughput approach.

Authors:  Ping Jin; Yingdong Zhao; Yvonne Ngalame; Monica C Panelli; Dirk Nagorsen; Vladia Monsurró; Kina Smith; Nan Hu; Hua Su; Phil R Taylor; Francesco M Marincola; Ena Wang
Journal:  BMC Genomics       Date:  2004-08-13       Impact factor: 3.969
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  8 in total

Review 1.  Immunogenomics and systems biology of vaccines.

Authors:  Luigi Buonaguro; Bali Pulendran
Journal:  Immunol Rev       Date:  2011-01       Impact factor: 12.988

2.  Immune signatures in human PBMCs of idiotypic vaccine for HCV-related lymphoproliferative disorders.

Authors:  Luigi Buonaguro; Annacarmen Petrizzo; Marialina Tornesello; Maria Napolitano; Debora Martorelli; Giuseppe Castello; Gerardo Beneduce; Amalia De Renzo; Oreste Perrella; Luca Romagnoli; Vitor Sousa; Valli De Re; Riccardo Dolcetti; Franco M Buonaguro
Journal:  J Transl Med       Date:  2010-02-19       Impact factor: 5.531

Review 3.  Systems biology applied to vaccine and immunotherapy development.

Authors:  Luigi Buonaguro; Ena Wang; Maria Lina Tornesello; Franco M Buonaguro; Francesco M Marincola
Journal:  BMC Syst Biol       Date:  2011-09-20

4.  Peripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system.

Authors:  Katrin Sikk; Sulev Kõks; Ursel Soomets; Leonard C Schalkwyk; Cathy Fernandes; Sulev Haldre; Sten-Magnus Aquilonius; Pille Taba
Journal:  Front Genet       Date:  2011-08-19       Impact factor: 4.599

Review 5.  Systems Biology Approach for Cancer Vaccine Development and Evaluation.

Authors:  Luisa Circelli; Annacarmen Petrizzo; Maria Tagliamonte; Maria Lina Tornesello; Franco M Buonaguro; Luigi Buonaguro
Journal:  Vaccines (Basel)       Date:  2015-07-14

6.  Systems Biology Analysis of the Radiation-Attenuated Schistosome Vaccine Reveals a Role for Growth Factors in Protection and Hemostasis Inhibition in Parasite Survival.

Authors:  Leonardo Paiva Farias; Juliana Vitoriano-Souza; Lucas Esteves Cardozo; Leonardo Dos Reis Gama; Youvika Singh; Patrícia Aoki Miyasato; Giulliana Tessarin Almeida; Dunia Rodriguez; Mayra Mara Ferrari Barbosa; Rafaela Sachetto Fernandes; Tereza Cristina Barbosa; Almiro Pires da Silva Neto; Eliana Nakano; Paulo Lee Ho; Sergio Verjovski-Almeida; Helder Imoto Nakaya; Robert Alan Wilson; Luciana Cezar de Cerqueira Leite
Journal:  Front Immunol       Date:  2021-03-11       Impact factor: 7.561

7.  Pattern of activation of human antigen presenting cells by genotype GII.4 norovirus virus-like particles.

Authors:  Eleonora Ponterio; Annacarmen Petrizzo; Ilaria Di Bartolo; Franco Maria Buonaguro; Luigi Buonaguro; Franco Maria Ruggeri
Journal:  J Transl Med       Date:  2013-05-24       Impact factor: 5.531

8.  Microarray analysis of microRNA expression in peripheral blood mononuclear cells of critically ill patients with influenza A (H1N1).

Authors:  Hao Song; Qi Wang; Yang Guo; Shunai Liu; Rui Song; Xuesong Gao; Li Dai; Baoshun Li; Deli Zhang; Jun Cheng
Journal:  BMC Infect Dis       Date:  2013-06-03       Impact factor: 3.090
  8 in total

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