BACKGROUND: The purpose of this prospective, randomized study was to compare the safety and efficacy of oral versus i.v. midazolam in providing sedation for pediatric upper gastrointestinal (GI) endoscopy. METHODS:Sixty-one children (age <16 years) scheduled for upper GI endoscopy were studied. Patients were randomly assigned to receive oral or i.v. midazolam. Measurements were made and compared for vital signs, level of sedation, pre- and post-procedure comfort, anxiety during endoscopy, ease of separation from parents, ease and duration of procedure, and recovery time. RESULTS:Patients were aged 1-16 years (mean 7.5 + or - 3.42 years); 30 patients receivedoral medication, and 31 received i.v. medication. There were no statistically significant differences in age or gender between groups. There were no significant differences in level of sedation, ease of separation from parents, ease of ability to monitor the patient during the procedure, heart rate, systolic arterial pressure, or respiratory rate. Oxygen saturation was significantly lower in the i.v. group than the oral group 10 and 30 min after removal of the endoscope, and recovery time was longer in the oral than the i.v. group. CONCLUSIONS: Oral administration of midazolam is a safe and effective method of sedation that significantly reduces anxiety and improves overall tolerance for children undergoing esophagogastroduodenoscopy.
RCT Entities:
BACKGROUND: The purpose of this prospective, randomized study was to compare the safety and efficacy of oral versus i.v. midazolam in providing sedation for pediatric upper gastrointestinal (GI) endoscopy. METHODS: Sixty-one children (age <16 years) scheduled for upper GI endoscopy were studied. Patients were randomly assigned to receive oral or i.v. midazolam. Measurements were made and compared for vital signs, level of sedation, pre- and post-procedure comfort, anxiety during endoscopy, ease of separation from parents, ease and duration of procedure, and recovery time. RESULTS:Patients were aged 1-16 years (mean 7.5 + or - 3.42 years); 30 patients received oral medication, and 31 received i.v. medication. There were no statistically significant differences in age or gender between groups. There were no significant differences in level of sedation, ease of separation from parents, ease of ability to monitor the patient during the procedure, heart rate, systolic arterial pressure, or respiratory rate. Oxygen saturation was significantly lower in the i.v. group than the oral group 10 and 30 min after removal of the endoscope, and recovery time was longer in the oral than the i.v. group. CONCLUSIONS: Oral administration of midazolam is a safe and effective method of sedation that significantly reduces anxiety and improves overall tolerance for children undergoing esophagogastroduodenoscopy.
Authors: Yoo Min Lee; Ben Kang; Yu Bin Kim; Hyun Jin Kim; Kyung Jae Lee; Yoon Lee; So Yoon Choi; Eun Hye Lee; Dae Yong Yi; Hyo Jeong Jang; You Jin Choi; Suk Jin Hong; Ju Young Kim; Yunkoo Kang; Soon Chul Kim Journal: J Korean Med Sci Date: 2021-05-24 Impact factor: 2.153
Authors: Vahid Sebghatollahi; Elham Tabesh; Ali Gholamrezaei; Amir Reza Zandi; Mohammad Minakari; Ahmad Shavakhi Journal: J Res Med Sci Date: 2017-12-26 Impact factor: 1.852