Literature DB >> 19661704

Enantioselective synthesis of aspergillide B.

Tomohiro Nagasawa1, Shigefumi Kuwahara.   

Abstract

The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.

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Year:  2009        PMID: 19661704     DOI: 10.1271/bbb.90221

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN: 0916-8451            Impact factor:   2.043


  3 in total

1.  Transition-metal-catalyzed synthesis of aspergillide B: an alkyne addition strategy.

Authors:  Barry M Trost; Mark J Bartlett
Journal:  Org Lett       Date:  2012-02-22       Impact factor: 6.005

2.  Enantioselective formal total synthesis of (+)-aspergillide C.

Authors:  Joseph D Panarese; Stephen P Waters
Journal:  Org Lett       Date:  2009-11-05       Impact factor: 6.005

3.  A carbohydrate approach for the formal total synthesis of (-)-aspergillide C.

Authors:  Pabbaraja Srihari; Namballa Hari Krishna; Ydhyam Sridhar; Ahmed Kamal
Journal:  Beilstein J Org Chem       Date:  2014-12-23       Impact factor: 2.883

  3 in total

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