Literature DB >> 19660859

Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line.

Jennifer E Foreman1, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Jeffrey M Peters.   

Abstract

The effects of ligand activation of PPARbeta/delta were examined in the mouse mammary tumor cell line (C20). Expression of PPARbeta/delta was markedly lower in C20 cells as compared to the human non-tumorigenic mammary gland derived cell line (MCF10A) and mouse keratinocytes. Ligand activation of PPARbeta/delta in C20 cells caused upregulation of the PPARbeta/delta target gene angiopoietin-like 4 (Angptl4). Inhibition of C20 cell proliferation and clonogenicity was observed following treatment with GW0742 or GW501516, two highly specific PPARbeta/delta ligands. In addition, an increase in apoptosis was observed in C20 cells cultured with 10microM GW501516 that preceded the observed inhibition of cell proliferation. Results from this study show that proliferation of the C20 mouse mammary gland cancer cell line is inhibited by ligand activation of PPARbeta/delta due in part to increased apoptosis. 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19660859      PMCID： PMC2815252          DOI： 10.1016/j.canlet.2009.07.006

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   9.756


  33 in total

Review 1.  GW-501516 GlaxoSmithKline/Ligand.

Authors:  Patricia Pelton
Journal:  Curr Opin Investig Drugs       Date:  2006-04

2.  Regulation of vascular endothelial cell growth factor expression in mouse mammary tumor cells by the EP2 subtype of the prostaglandin E2 receptor.

Authors:  Sung-Hee Chang; Catherine H Liu; Ming-Tao Wu; Timothy Hla
Journal:  Prostaglandins Other Lipid Mediat       Date:  2005-03-17       Impact factor: 3.072

Review 3.  PPARbeta/delta ligands as modulators of the inflammatory response.

Authors:  Kenneth S Kilgore; Andrew N Billin
Journal:  Curr Opin Investig Drugs       Date:  2008-05

4.  Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity.

Authors:  Dae J Kim; Iain A Murray; Amanda M Burns; Frank J Gonzalez; Gary H Perdew; Jeffrey M Peters
Journal:  J Biol Chem       Date:  2005-01-04       Impact factor: 5.157

5.  Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice.

Authors:  Elizabeth E Girroir; Holly E Hollingshead; Pengfei He; Bokai Zhu; Gary H Perdew; Jeffrey M Peters
Journal:  Biochem Biophys Res Commun       Date:  2008-04-28       Impact factor: 3.575

6.  PPARdelta is pro-tumorigenic in a mouse model of COX-2-induced mammary cancer.

Authors:  Mallika Ghosh; Youxi Ai; Kirsi Narko; Zhenglong Wang; Jeffrey M Peters; Timothy Hla
Journal:  Prostaglandins Other Lipid Mediat       Date:  2008-12-24       Impact factor: 3.072

7.  Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

Authors:  Ruth L Stephen; Mattias C U Gustafsson; Morag Jarvis; Roger Tatoud; Barry R Marshall; Deborah Knight; Ewa Ehrenborg; Adrian L Harris; C Roland Wolf; Colin N A Palmer
Journal:  Cancer Res       Date:  2004-05-01       Impact factor: 12.701

8.  Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice.

Authors:  Sabine Müller-Brüsselbach; Martin Kömhoff; Markus Rieck; Wolfgang Meissner; Kerstin Kaddatz; Jürgen Adamkiewicz; Boris Keil; Klaus J Klose; Roland Moll; Andrew D Burdick; Jeffrey M Peters; Rolf Müller
Journal:  EMBO J       Date:  2007-07-19       Impact factor: 11.598

9.  Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands inhibit growth of UACC903 and MCF7 human cancer cell lines.

Authors:  Elizabeth E Girroir; Holly E Hollingshead; Andrew N Billin; Timothy M Willson; Gavin P Robertson; Arun K Sharma; Shantu Amin; Frank J Gonzalez; Jeffrey M Peters
Journal:  Toxicology       Date:  2007-11-04       Impact factor: 4.571

10.  Regulation of Cell Proliferation and Differentiation by PPARbeta/delta.

Authors:  Rolf Müller; Markus Rieck; Sabine Müller-Brüsselbach
Journal:  PPAR Res       Date:  2008       Impact factor: 4.964
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  12 in total

1.  Apoptotic effect of the selective PPARβ/δ agonist GW501516 in invasive bladder cancer cells.

Authors:  Adeline Péchery; Sylvie Fauconnet; Hugues Bittard; Isabelle Lascombe
Journal:  Tumour Biol       Date:  2016-09-16

Review 2.  Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis.

Authors:  Jeffrey M Peters; Jennifer E Foreman; Frank J Gonzalez
Journal:  Cancer Metastasis Rev       Date:  2011-12       Impact factor: 9.264

3.  Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment.

Authors:  H-Y Hsieh; Y-C Jou; C-L Tung; Y-S Tsai; Y-H Wang; C-L Chi; R-I Lin; S-K Hung; Y-M Chuang; S-F Wu; C Li; C-H Shen; M W Y Chan; C-D Hsu
Journal:  Oncogene       Date:  2017-10-16       Impact factor: 9.867

4.  Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer.

Authors:  Jennifer E Foreman; Wen-Chi L Chang; Prajakta S Palkar; Bokai Zhu; Michael G Borland; Jennie L Williams; Lance R Kramer; Margie L Clapper; Frank J Gonzalez; Jeffrey M Peters
Journal:  Mol Carcinog       Date:  2011-03-11       Impact factor: 4.784

5.  Activation of peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) inhibits human breast cancer cell line tumorigenicity.

Authors:  Pei-Li Yao; Jose L Morales; Bokai Zhu; Boo-Hyon Kang; Frank J Gonzalez; Jeffrey M Peters
Journal:  Mol Cancer Ther       Date:  2014-01-24       Impact factor: 6.261

6.  Profiling of mRNA and long non-coding RNA of urothelial cancer in recipients after renal transplantation.

Authors:  Donghao Shang; Tie Zheng; Jian Zhang; Ye Tian; Yuting Liu
Journal:  Tumour Biol       Date:  2016-07-22

7.  Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.

Authors:  Prajakta S Palkar; Michael G Borland; Simone Naruhn; Christina H Ferry; Christina Lee; Ugir H Sk; Arun K Sharma; Shantu Amin; Iain A Murray; Cherie R Anderson; Gary H Perdew; Frank J Gonzalez; Rolf Müller; Jeffrey M Peters
Journal:  Mol Pharmacol       Date:  2010-06-01       Impact factor: 4.054

8.  PPARδ regulates satellite cell proliferation and skeletal muscle regeneration.

Authors:  Alison R Angione; Chunhui Jiang; Dongning Pan; Yong-Xu Wang; Shihuan Kuang
Journal:  Skelet Muscle       Date:  2011-11-01       Impact factor: 4.912

9.  Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231.

Authors:  Masoumeh Tavakoli Yaraki; Fatemeh Karami Tehrani
Journal:  Iran J Basic Med Sci       Date:  2013-04       Impact factor: 2.699

10.  Apoptosis Induced by 13-S-hydroxyoctadecadienoic acid in the Breast Cancer Cell Lines, MCF-7 and MDA-MB-231.

Authors:  Masoumeh Tavakoli Yaraki; Fatemeh Karami Tehrani
Journal:  Iran J Basic Med Sci       Date:  2013-04       Impact factor: 2.699
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