| Literature DB >> 19660858 |
Takahiro Yaguchi1, Masakazu Muramoto, Takashi Nakano, Tomoyuki Nishizaki.
Abstract
Urinary trypsin inhibitor (UTI), an inhibitor of urokinase plasminogen activator relevant to proteolytic processing from the inactive into the active form of platelet-derived growth factor-D (PDGF-D) to activate PDGF-betabeta receptor (PDGF-betabetaR), inhibited fetal bovine serum-stimulated migration of human malignant mesothelioma, with the extent varying among the cell types. The more effective inhibition was found in NCIH-2052 and -2452 cells, with the higher expression of PDGF-betabetaR. The results of the present study suggest that UTI suppresses malignant mesothelioma cell migration by neutralizing active dimer of PDGF-D (PDGF-DD)/PDGF-betabetaR-mediated signal transduction. 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 19660858 DOI： 10.1016/j.canlet.2009.07.003
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679