Literature DB >> 19660820

Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy.

Afshan N Malik1, Rojeen Shahni, Masud M Iqbal.   

Abstract

We report that mitochondrial DNA (MtDNA) copy numbers are increased in peripheral blood of patients with diabetic nephropathy (DN). Using qPCR for quantitation, we found a 2-4-fold significant increase (p<0.05) in the mean MtDNA values in DN patients vs. healthy controls and diabetics without nephropathy. Increased MtDNA in DN could contribute to increased oxidative stress.

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Year:  2009        PMID： 19660820     DOI： 10.1016/j.diabres.2009.07.002

Source DB:  PubMed          Journal:  Diabetes Res Clin Pract        ISSN： 0168-8227            Impact factor:   5.602


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