Literature DB >> 19660811

A novel mouse model for the aggressive variant of NK cell and T cell large granular lymphocyte leukemia.

Akihiko Yokohama1, Anjali Mishra, Takeki Mitsui, Brian Becknell, Jessica Johns, Douglas Curphey, Bradley W Blaser, Jeffrey B Vandeusen, Hsiaoyin Mao, Jianhua Yu, Michael A Caligiuri.   

Abstract

Murine models of disease are vital to the understanding of pathogenesis and the development of novel therapeutics. We have previously established interleukin (IL)-15 transgenic (tg) mice that demonstrate rapid proliferation of natural killer (NK) and T cells, followed by spontaneous transformation to lethal leukemia. Herein, we have characterized this model, which has many features in common with the aggressive variants of NK and T large granular lymphocyte leukemia (LGLL) in humans. The LGLL blasts are cytolytic and produce IFN-gammaex vivo. Cytogenetic analysis revealed trisomy of chromosome 17 and/or 15. This model should provide opportunities to develop effective standard therapies for this fatal disease. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19660811      PMCID： PMC2814907          DOI： 10.1016/j.leukres.2009.06.031

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  29 in total

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Authors:  Michelle M Le Beau; Sheila Bitts; Elizabeth M Davis; Scott C Kogan
Journal:  Blood       Date:  2002-04-15       Impact factor: 22.113

3.  Fulminant clonal expansion of large granular lymphocytes. Characterization of their morphology, phenotype, genotype, and function.

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Journal:  Cancer       Date:  1988-11-01       Impact factor: 6.860

4.  Is trisomy cause or consequence of murine T cell leukemia development? Studies on Robertsonian translocation mice.

Authors:  J Spira; F Wiener; S Ohno; G Klein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

5.  Relevance of trisomy 15 and other chromosome abnormalities in spontaneous AKR leukemia of mice with and without Robertsonian rearrangement.

Authors:  E W Herbst; A Gropp
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

6.  TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder.

Authors:  Margarida Lima; Julia Almeida; Maria Dos Anjos Teixeira; Maria del Carmen Alguero Md; Ana Helena Santos; Ana Balanzategui; Maria Luís Queirós; Paloma Bárcena; Antonio Izarra; Sónia Fonseca; Clara Bueno; Benvindo Justiça; Marcos Gonzalez; Jesús F San Miguel; Alberto Orfao
Journal:  Am J Pathol       Date:  2003-08       Impact factor: 4.307

7.  Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells.

Authors:  J H Gong; G Maki; H G Klingemann
Journal:  Leukemia       Date:  1994-04       Impact factor: 11.528

8.  A case of chronic lymphocytic leukemia with properties characteristic of natural killer cells.

Authors:  K Itoh; K Tsuchikawa; T Awataguchi; K Shiiba; K Kumagai
Journal:  Blood       Date:  1983-05       Impact factor: 22.113

9.  T cells expressing both L-selectin and CD44 molecules increase in number in peritoneal exudate cells and in vitro-stimulated spleen cells from mice immunized intraperitoneally with Listeria monocytogenes.

Authors:  X Y Li; G Matsuzaki; Y Yoshikai; K Muramori; K Nomoto
Journal:  Immunology       Date:  1993-01       Impact factor: 7.397

10.  CD3+, CD56+ aggressive variant of large granular lymphocyte leukemia.

Authors:  T C Gentile; A H Uner; R E Hutchison; J Wright; J Ben-Ezra; E C Russell; T P Loughran
Journal:  Blood       Date:  1994-10-01       Impact factor: 22.113
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  8 in total

1.  NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.

Authors:  Jianhua Yu; Takeki Mitsui; Min Wei; Hsiaoyin Mao; Jonathan P Butchar; Mithun Vinod Shah; Jianying Zhang; Anjali Mishra; Christopher Alvarez-Breckenridge; Xingluo Liu; Shujun Liu; Akihiko Yokohama; Rossana Trotta; Guido Marcucci; Don M Benson; Thomas P Loughran; Susheela Tridandapani; Michael A Caligiuri
Journal:  J Clin Invest       Date:  2011-04       Impact factor: 14.808

2.  Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.

Authors:  Noriko Sato; Helen Sabzevari; Song Fu; Wei Ju; Michael N Petrus; Richard N Bamford; Thomas A Waldmann; Yutaka Tagaya
Journal:  Blood       Date:  2011-02-08       Impact factor: 22.113

3.  Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation.

Authors:  Anjali Mishra; Shujun Liu; Gregory H Sams; Douglas P Curphey; Ramasamy Santhanam; Laura J Rush; Deanna Schaefer; Lauren G Falkenberg; Laura Sullivan; Laura Jaroncyk; Xiaojuan Yang; Harold Fisk; Lai-Chu Wu; Christopher Hickey; Jason C Chandler; Yue-Zhong Wu; Nyla A Heerema; Kenneth K Chan; Danilo Perrotti; Jianying Zhang; Pierluigi Porcu; Frederick K Racke; Ramiro Garzon; Robert J Lee; Guido Marcucci; Michael A Caligiuri
Journal:  Cancer Cell       Date:  2012-11-13       Impact factor: 31.743

Review 4.  Molecular pathways: interleukin-15 signaling in health and in cancer.

Authors:  Anjali Mishra; Laura Sullivan; Michael A Caligiuri
Journal:  Clin Cancer Res       Date:  2014-04-15       Impact factor: 12.531

5.  Cbl-b Is Upregulated and Plays a Negative Role in Activated Human NK Cells.

Authors:  Ting Lu; Li Chen; Anthony G Mansour; Melissa J Yu; Noah Brooks; Kun-Yu Teng; Zhenlong Li; Jianying Zhang; Tasha Barr; Jianhua Yu; Michael A Caligiuri
Journal:  J Immunol       Date:  2021-01-08       Impact factor: 5.426

Review 6.  Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice.

Authors:  Joo-Young Park; Davinna L Ligons; Jung-Hyun Park
Journal:  Immune Netw       Date:  2018-02-22       Impact factor: 6.303

7.  STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia.

Authors:  Klara Klein; Agnieszka Witalisz-Siepracka; Barbara Maurer; Daniela Prinz; Gerwin Heller; Nicoletta Leidenfrost; Michaela Prchal-Murphy; Tobias Suske; Richard Moriggl; Veronika Sexl
Journal:  Leukemia       Date:  2019-04-09       Impact factor: 11.528

Review 8.  Cytokines in the Pathogenesis of Large Granular Lymphocytic Leukemia.

Authors:  Colleen Isabelle; Amy Boles; Nitin Chakravarti; Pierluigi Porcu; Jonathan Brammer; Anjali Mishra
Journal:  Front Oncol       Date:  2022-03-10       Impact factor: 6.244
  8 in total

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