BACKGROUND: Basal cell carcinoma (BCC) of the nipple-areola complex is uncommon. It has been suggested that BCCs in this region behave more aggressively, with a higher potential for distant spread, than in other anatomical sites. OBJECTIVE: To address questions about etiology, behavior, optimal treatment, and prognosis of this entity. METHODS AND MATERIALS: A literature search identifying all cases of BCC of the nipple and nipple-areola complex in the English literature from 1893 to 2008. RESULTS: Thirty-four cases of BCC of the nipple, areola, or both were identified, mostly affecting middle-aged men. The majority of patients were treated with tissue-sparing surgery. There was a metastatic rate of 9.1%, and one patient died from the disease (3.0%). CONCLUSIONS: The optimal treatment of this condition should be local excision, but patients with this condition should be followed up for primary site recurrence and axillary metastasis, because there is greater incidence than with BCC at other anatomical sites. Furthermore, proven axillary metastasis should be surgically treated.
BACKGROUND:Basal cell carcinoma (BCC) of the nipple-areola complex is uncommon. It has been suggested that BCCs in this region behave more aggressively, with a higher potential for distant spread, than in other anatomical sites. OBJECTIVE: To address questions about etiology, behavior, optimal treatment, and prognosis of this entity. METHODS AND MATERIALS: A literature search identifying all cases of BCC of the nipple and nipple-areola complex in the English literature from 1893 to 2008. RESULTS: Thirty-four cases of BCC of the nipple, areola, or both were identified, mostly affecting middle-aged men. The majority of patients were treated with tissue-sparing surgery. There was a metastatic rate of 9.1%, and one patient died from the disease (3.0%). CONCLUSIONS: The optimal treatment of this condition should be local excision, but patients with this condition should be followed up for primary site recurrence and axillary metastasis, because there is greater incidence than with BCC at other anatomical sites. Furthermore, proven axillary metastasis should be surgically treated.
Authors: Han Jin Jung; Jae Hun Jun; Ho Youn Kim; Seok-Jong Lee; Do Won Kim; Weon Ju Lee; Jin Hyang Jung Journal: Ann Dermatol Date: 2011-10-31 Impact factor: 1.444
Authors: Baltasar Melo Neto; Giuliano da Paz Oliveira; Sabas Carlos Vieira; Livio Rodrigues Leal; José Andrade de Carvalho Melo Junior; Cyro Franklin Vieira Journal: An Bras Dermatol Date: 2013 Mar-Apr Impact factor: 1.896