BACKGROUND: Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and occasionally death, in young adults. Several lines of evidence suggest a genetic predisposition to CAD. However, previous genetic studies have been inconclusive mainly due to insufficient numbers of patients. Our hypothesis is that CAD is a multifactorial disease caused by yet largely unidentified genetic variants and environmental factors, which may interact. Our aim is to identify genetic variants associated with an increased risk of CAD and possibly gene-environment interactions. METHODS: We organized a multinational European network, Cervical Artery Dissection and Ischemic Stroke Patients (CADISP), which aims at increasing our knowledge of the pathophysiological mechanisms of this disease in a large group of patients. Within this network, we are aiming to perform a de novo genetic association analysis using both a genome-wide and a candidate gene approach. For this purpose, DNA from approximately 1100 patients with CAD, and 2000 healthy controls is being collected. In addition, detailed clinical, laboratory, diagnostic, therapeutic, and outcome data are being collected from all participants applying predefined criteria and definitions in a standardized way. We are expecting to reach the above numbers of subjects by early 2009. CONCLUSIONS: We present the strategy of a collaborative project searching for the genetic risk factors of CAD. The CADISP network will provide detailed and novel data on environmental risk factors and genetic susceptibility to CAD.
BACKGROUND: Cervical artery dissection (CAD) is a frequent cause of ischemic stroke, and occasionally death, in young adults. Several lines of evidence suggest a genetic predisposition to CAD. However, previous genetic studies have been inconclusive mainly due to insufficient numbers of patients. Our hypothesis is that CAD is a multifactorial disease caused by yet largely unidentified genetic variants and environmental factors, which may interact. Our aim is to identify genetic variants associated with an increased risk of CAD and possibly gene-environment interactions. METHODS: We organized a multinational European network, Cervical Artery Dissection and Ischemic StrokePatients (CADISP), which aims at increasing our knowledge of the pathophysiological mechanisms of this disease in a large group of patients. Within this network, we are aiming to perform a de novo genetic association analysis using both a genome-wide and a candidate gene approach. For this purpose, DNA from approximately 1100 patients with CAD, and 2000 healthy controls is being collected. In addition, detailed clinical, laboratory, diagnostic, therapeutic, and outcome data are being collected from all participants applying predefined criteria and definitions in a standardized way. We are expecting to reach the above numbers of subjects by early 2009. CONCLUSIONS: We present the strategy of a collaborative project searching for the genetic risk factors of CAD. The CADISP network will provide detailed and novel data on environmental risk factors and genetic susceptibility to CAD.
Authors: Manja Kloss; Antti Metso; Alessandro Pezzini; Didier Leys; Maurice Giroud; Tiina M Metso; Turgut Tatlisumak; Christoph Lichy; Anna Bersano; Shérine Abboud; Armin Grau; Philippe A Lyrer; Stéphanie Debette; Jean Dallongeville; Juan Martin; Valeria Caso; Caspar Grond-Ginsbach; Stefan T Engelter Journal: J Neurol Date: 2012-08 Impact factor: 4.849
Authors: Stéphanie Debette; Yoichiro Kamatani; Tiina M Metso; Manja Kloss; Ganesh Chauhan; Stefan T Engelter; Alessandro Pezzini; Vincent Thijs; Hugh S Markus; Martin Dichgans; Christiane Wolf; Ralf Dittrich; Emmanuel Touzé; Andrew M Southerland; Yves Samson; Shérine Abboud; Yannick Béjot; Valeria Caso; Anna Bersano; Andreas Gschwendtner; Maria Sessa; John Cole; Chantal Lamy; Elisabeth Medeiros; Simone Beretta; Leo H Bonati; Armin J Grau; Patrik Michel; Jennifer J Majersik; Pankaj Sharma; Ludmila Kalashnikova; Maria Nazarova; Larisa Dobrynina; Eva Bartels; Benoit Guillon; Evita G van den Herik; Israel Fernandez-Cadenas; Katarina Jood; Michael A Nalls; Frank-Erik De Leeuw; Christina Jern; Yu-Ching Cheng; Inge Werner; Antti J Metso; Christoph Lichy; Philippe A Lyrer; Tobias Brandt; Giorgio B Boncoraglio; Heinz-Erich Wichmann; Christian Gieger; Andrew D Johnson; Thomas Böttcher; Maurizio Castellano; Dominique Arveiler; M Arfan Ikram; Monique M B Breteler; Alessandro Padovani; James F Meschia; Gregor Kuhlenbäumer; Arndt Rolfs; Bradford B Worrall; Erich-Bernd Ringelstein; Diana Zelenika; Turgut Tatlisumak; Mark Lathrop; Didier Leys; Philippe Amouyel; Jean Dallongeville Journal: Nat Genet Date: 2014-11-24 Impact factor: 38.330
Authors: Stéphanie Debette; Barbara Goeggel Simonetti; Sabrina Schilling; Juan José Martin; Manja Kloss; Hakan Sarikaya; Ingrid Hausser; Stefan Engelter; Tiina M Metso; Alessandro Pezzini; Vincent Thijs; Emmanuel Touzé; Stefano Paolucci; Paolo Costa; Maria Sessa; Yves Samson; Yannick Béjot; Ayse Altintas; Antti J Metso; Dominique Hervé; Christoph Lichy; Simon Jung; Urs Fischer; Chantal Lamy; Armin Grau; Hugues Chabriat; Valeria Caso; Philippe A Lyrer; Christian Stapf; Turgut Tatlisumak; Tobias Brandt; Elisabeth Tournier-Lasserve; Dominique P Germain; Michael Frank; Ralf W Baumgartner; Caspar Grond-Ginsbach; Marie-Germaine Bousser; Didier Leys; Jean Dallongeville; Anna Bersano; Marcel Arnold Journal: Neurology Date: 2014-10-29 Impact factor: 9.910
Authors: Tiina M Metso; Stéphanie Debette; Caspar Grond-Ginsbach; Stefan T Engelter; Didier Leys; Tobias Brandt; Alessandro Pezzini; Anna Bersano; Manja Kloss; Vincent Thijs; Philippe A Lyrer; Turgut Tatlisumak; Antti J Metso Journal: J Neurol Date: 2012-04-18 Impact factor: 4.849
Authors: Lars Kellert; Armin Grau; Alessandro Pezzini; Stéphanie Debette; Didier Leys; Valeria Caso; Vincent N Thijs; Anna Bersano; Emmanuel Touzé; Turgut Tatlisumak; Christopher Traenka; Philippe A Lyrer; Stefan T Engelter; Tiina M Metso; Caspar Grond-Ginsbach; Manja Kloss Journal: J Neurol Date: 2018-02-24 Impact factor: 4.849