| Literature DB >> 19658393 |
Martin D Witte1, Bogdan I Florea, Martijn Verdoes, Oloruntosin Adeyanju, Gijs A Van der Marel, Herman S Overkleeft.
Abstract
Cytosolic and nuclear proteins may be subject to both O-GlcNAcylation and proteasomal degradation. By means of activity-based profiling, we demonstrate that O-GlcNAc serine-containing peptide epoxyketones bind to the proteasome catalytic active sites and thus provide the first clear evidence that proteasomes recognize peptides post-translationally modified with a GlcNAc moiety.Entities:
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Year: 2009 PMID： 19658393 DOI： 10.1021/ja901231w
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419