BACKGROUND: Few studies have analysed the importance of haptoglobin (Hp) as a risk factor for acute myocardial infarction (AMI), stroke, and heart failure (HF) in large healthy populations. AIMS: We examined Hp as risk factor for AMI, stroke, and HF in the Apolipoprotein MOrtality RISk (AMORIS) Study and compared its predictive strength with that of total serum cholesterol (TC). METHODS: Prospective study (11.8 years) of AMI, stroke, and HF through linkage with Swedish hospital discharge and mortality registers with measurements of Hp in 342,125 subjects. RESULTS: Hp is a significant risk factor of AMI, stroke, and HF. Relationships were stronger for men than women with regard to stroke and HF, but not AMI. Hp was almost as predictive as TC for AMI and about equally predictive of stroke with a stronger relationship to ischaemic than haemorrhagic stroke. A 4.2-fold increase in risk of AMI was observed comparing subjects in the joint lower quartiles of TC and Hp to those in the upper. For stroke, the risk increase was 2-fold, and 1.5-fold for HF. INTERPRETATION: The inflammation marker Hp carried as much additional predictive information value on AMI and stroke as TC. Hp was also a risk factor of HF.
BACKGROUND: Few studies have analysed the importance of haptoglobin (Hp) as a risk factor for acute myocardial infarction (AMI), stroke, and heart failure (HF) in large healthy populations. AIMS: We examined Hp as risk factor for AMI, stroke, and HF in the Apolipoprotein MOrtality RISk (AMORIS) Study and compared its predictive strength with that of total serum cholesterol (TC). METHODS: Prospective study (11.8 years) of AMI, stroke, and HF through linkage with Swedish hospital discharge and mortality registers with measurements of Hp in 342,125 subjects. RESULTS: Hp is a significant risk factor of AMI, stroke, and HF. Relationships were stronger for men than women with regard to stroke and HF, but not AMI. Hp was almost as predictive as TC for AMI and about equally predictive of stroke with a stronger relationship to ischaemic than haemorrhagic stroke. A 4.2-fold increase in risk of AMI was observed comparing subjects in the joint lower quartiles of TC and Hp to those in the upper. For stroke, the risk increase was 2-fold, and 1.5-fold for HF. INTERPRETATION: The inflammation marker Hp carried as much additional predictive information value on AMI and stroke as TC. Hp was also a risk factor of HF.
Authors: Upendra Chalise; Mediha Becirovic-Agic; Jocelyn R Rodriguez-Paar; Shelby R Konfrst; Sharon D B de Morais; Catherine S Johnson; Elizabeth R Flynn; Michael E Hall; Daniel R Anderson; Leah M Cook; Kristine Y DeLeon-Pennell; Merry L Lindsey Journal: J Cardiovasc Transl Res Date: 2022-10-05 Impact factor: 3.216
Authors: Tibor V Varga; Azra Kurbasic; Mattias Aine; Pontus Eriksson; Ashfaq Ali; George Hindy; Stefan Gustafsson; Jian'an Luan; Dmitry Shungin; Yan Chen; Christina-Alexandra Schulz; Peter M Nilsson; Göran Hallmans; Inês Barroso; Panos Deloukas; Claudia Langenberg; Robert A Scott; Nicholas J Wareham; Lars Lind; Erik Ingelsson; Olle Melander; Marju Orho-Melander; Frida Renström; Paul W Franks Journal: Int J Epidemiol Date: 2017-08-01 Impact factor: 7.196
Authors: Joanna M M Howson; Wei Zhao; Daniel R Barnes; Weang-Kee Ho; Robin Young; Dirk S Paul; Lindsay L Waite; Daniel F Freitag; Eric B Fauman; Elias L Salfati; Benjamin B Sun; John D Eicher; Andrew D Johnson; Wayne H H Sheu; Sune F Nielsen; Wei-Yu Lin; Praveen Surendran; Anders Malarstig; Jemma B Wilk; Anne Tybjærg-Hansen; Katrine L Rasmussen; Pia R Kamstrup; Panos Deloukas; Jeanette Erdmann; Sekar Kathiresan; Nilesh J Samani; Heribert Schunkert; Hugh Watkins; Ron Do; Daniel J Rader; Julie A Johnson; Stanley L Hazen; Arshed A Quyyumi; John A Spertus; Carl J Pepine; Nora Franceschini; Anne Justice; Alex P Reiner; Steven Buyske; Lucia A Hindorff; Cara L Carty; Kari E North; Charles Kooperberg; Eric Boerwinkle; Kristin Young; Mariaelisa Graff; Ulrike Peters; Devin Absher; Chao A Hsiung; Wen-Jane Lee; Kent D Taylor; Ying-Hsiang Chen; I-Te Lee; Xiuqing Guo; Ren-Hua Chung; Yi-Jen Hung; Jerome I Rotter; Jyh-Ming J Juang; Thomas Quertermous; Tzung-Dau Wang; Asif Rasheed; Philippe Frossard; Dewan S Alam; Abdulla Al Shafi Majumder; Emanuele Di Angelantonio; Rajiv Chowdhury; Yii-Der Ida Chen; Børge G Nordestgaard; Themistocles L Assimes; John Danesh; Adam S Butterworth; Danish Saleheen Journal: Nat Genet Date: 2017-05-22 Impact factor: 41.307
Authors: Philippe Froguel; Ndeye Coumba Ndiaye; Amélie Bonnefond; Nabila Bouatia-Naji; Aurélie Dechaume; Gérard Siest; Bernard Herbeth; Mario Falchi; Leonardo Bottolo; Rosa-Maria Guéant-Rodriguez; Cécile Lecoeur; Michel R Langlois; Yann Labrune; Aimo Ruokonen; Said El Shamieh; Maria G Stathopoulou; Anita Morandi; Claudio Maffeis; David Meyre; Joris R Delanghe; Peter Jacobson; Lars Sjöström; Lena M S Carlsson; Andrew Walley; Paul Elliott; Marjo-Riita Jarvelin; George V Dedoussis; Sophie Visvikis-Siest Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240