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Literature DB >> 19656472

Abnormal skin barrier in the etiopathogenesis of atopic dermatitis.

Abstract

Prior studies revealed the key roles played by T-helper type 1 and type 2 (Th1/Th2) cell dysregulation, IgE production, mast cell hyperactivity, and dendritic cell signaling in the evolution of the chronic, pruritic, inflammatory dermatosis that characterizes atopic dermatitis (AD). Accordingly, current therapy has been largely directed toward ameliorating Th2-mediated inflammation and pruritus. This article reviews emerging evidence that the inflammation in AD results from inherited and acquired insults to the barrier, as well as the therapeutic implications of this new paradigm.

Entities: Disease Gene

Mesh：

Substances：

Year: 2009 PMID： 19656472 DOI： 10.1007/s11882-009-0037-y

Source DB: PubMed Journal: Curr Allergy Asthma Rep ISSN： 1529-7322 Impact factor: 4.806

67 in total

1. Does the tail wag the dog? Role of the barrier in the pathogenesis of inflammatory dermatoses and therapeutic implications.

Authors: P M Elias; K R Feingold
Journal: Arch Dermatol Date: 2001-08

2. IL-4 suppresses the recovery of cutaneous permeability barrier functions in vivo.

Authors: Rieko Kurahashi; Yutaka Hatano; Kazumoto Katagiri
Journal: J Invest Dermatol Date: 2007-10-25 Impact factor: 8.551

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Journal: J Invest Dermatol Date: 1994-11 Impact factor: 8.551

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Authors: I R Scott; C R Harding; J G Barrett
Journal: Biochim Biophys Acta Date: 1982-10-28

5. Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

Authors: Peck Y Ong; Takaaki Ohtake; Corinne Brandt; Ian Strickland; Mark Boguniewicz; Tomas Ganz; Richard L Gallo; Donald Y M Leung
Journal: N Engl J Med Date: 2002-10-10 Impact factor: 91.245

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Journal: Arch Dermatol Date: 2001-01

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Authors: Y Vasilopoulos; M J Cork; R Murphy; H C Williams; D A Robinson; G W Duff; S J Ward; R Tazi-Ahnini
Journal: J Invest Dermatol Date: 2004-07 Impact factor: 8.551

8. Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment.

Authors: I R Scott; C R Harding
Journal: Dev Biol Date: 1986-05 Impact factor: 3.582

9. The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease.

Authors: Jeffrey L Sugarman; Joachim W Fluhr; Ashley J Fowler; Thomas Bruckner; Thomas L Diepgen; Mary L Williams
Journal: Arch Dermatol Date: 2003-11

10. Filaggrin linker segment peptide and cystatin alpha are parts of a complex of the cornified envelope of epidermis.

Authors: M Takahashi; T Tezuka; N Katunuma
Journal: Arch Biochem Biophys Date: 1996-05-01 Impact factor: 4.013

22 in total

Review 1. Tight junctions in skin inflammation.

Authors: Katja Bäsler; Johanna M Brandner
Journal: Pflugers Arch Date: 2016-11-16 Impact factor: 3.657

Review 2. The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms.

Authors: Anna R Smith; George Knaysi; Jeffrey M Wilson; Julia A Wisniewski
Journal: Curr Allergy Asthma Rep Date: 2017-01 Impact factor: 4.806

Review 3. Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis.

Authors: Julia K Gittler; James G Krueger; Emma Guttman-Yassky
Journal: J Allergy Clin Immunol Date: 2012-08-28 Impact factor: 10.793

Review 4. Therapeutic Benefits of Natural Ingredients for Atopic Dermatitis.

Authors: George Man; Li-Zhi Hu; Peter M Elias; Mao-Qiang Man
Journal: Chin J Integr Med Date: 2017-09-01 Impact factor: 1.978

5. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.

Authors: Tiffany C Scharschmidt; Mao-Qiang Man; Yutaka Hatano; Debra Crumrine; Roshan Gunathilake; John P Sundberg; Kathleen A Silva; Theodora M Mauro; Melanie Hupe; Soyun Cho; Yan Wu; Anna Celli; Matthias Schmuth; Kenneth R Feingold; Peter M Elias
Journal: J Allergy Clin Immunol Date: 2009-09 Impact factor: 10.793

6. Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasis.

Authors: Elisa Domínguez-Hüttinger; Masahiro Ono; Mauricio Barahona; Reiko J Tanaka
Journal: Interface Focus Date: 2013-04-06 Impact factor: 3.906

7. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy.

Authors: Sara J Brown; Yuka Asai; Heather J Cordell; Linda E Campbell; Yiwei Zhao; Haihui Liao; Kate Northstone; John Henderson; Reza Alizadehfar; Moshe Ben-Shoshan; Kenneth Morgan; Graham Roberts; Laury J N Masthoff; Suzanne G M A Pasmans; Peter C van den Akker; Cisca Wijmenga; Jonathan O'B Hourihane; Colin N A Palmer; Gideon Lack; Ann Clarke; Peter R Hull; Alan D Irvine; W H Irwin McLean
Journal: J Allergy Clin Immunol Date: 2011-03 Impact factor: 10.793