OBJECTIVE: To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). METHODS: Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed. RESULTS: In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05). CONCLUSIONS: Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
OBJECTIVE: To investigate the effect of dexamethasone on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis (SAP). METHODS:Rats were randomly divided into sham-operated, model control, and dexamethasone-treated groups. At 3, 6, and 12 h after operation, the expression levels of P-selectin protein in one-third of the rats in each group were observed. RESULTS: In the treated group, the expression levels of P-selectin protein in the pancreas head (at 6 h), lung (at 12 h), liver (at 3 h), and spleen (at 6 and 12 h) were significantly lower than those in the model control group (P < 0.05). Additionally, the products of the staining intensity and positive rate of P-selectin protein in liver (at 3 h), lung (at 6 and 12 h), and spleen (at 12 h) in the treated group were significantly lower than those in the model control group (P < 0.05). CONCLUSIONS:Dexamethasone can inhibit P-selectin protein expression in multiple organs of SAP rats.
Authors: M Hirota; F Nozawa; A Okabe; M Shibata; T Beppu; S Shimada; H Egami; Y Yamaguchi; S Ikei; T Okajima; K Okamoto; M Ogawa Journal: Pancreas Date: 2000-08 Impact factor: 3.327
Authors: E Folch; A Salas; N Prats; J Panés; J M Piqué; E Gelpí; J Roselló-Catafau; D Closa Journal: Free Radic Biol Med Date: 2000-04-15 Impact factor: 7.376
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