Literature DB >> 19652435

Nonspecific interstitial pneumonia (NSIP) associated with anti-KS antibody: differentiation from idiopathic NSIP.

Kaori Okayasu1, Yoshio Ohtani, Tamiko Takemura, Ken Uchibori, Meiyo Tamaoka, Masashi Furuiye, Yasunari Miyazaki, Naohiko Inase, Yasuyuki Yoshizawa.   

Abstract

We report two cases of biopsy-proven nonspecific interstitial pneumonia (NSIP) with anti-KS (asparaginyl-tRNA) antibody. Anti-KS antibody is the sixth anti-aminoacyl-tRNA synthetase (ARS) antibody. They showed interstitial pneumonia without clinical symptoms, and high resolution computed tomography (HRCT) of the chest demonstrated consolidation along bronchovascular bundles and volume loss in the bilateral lower lobes, which were suggestive of connective tissue diseases (CTD). One case of cellular NSIP responded to corticosteroid, but the other case of fibrotic NSIP required corticosteroid and cyclosporin. In patients with these HRCT findings, the measurement of anti-ARS antibodies could be helpful even in the absence of clinical symptoms suggestive of CTD.

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Year:  2009        PMID： 19652435     DOI： 10.2169/internalmedicine.48.2207

Source DB:  PubMed          Journal:  Intern Med        ISSN： 0918-2918            Impact factor:   1.271


  7 in total

Review 1.  Myositis-related interstitial lung disease and antisynthetase syndrome.

Authors:  Joshua Solomon; Jeffrey J Swigris; Kevin K Brown
Journal:  J Bras Pneumol       Date:  2011 Jan-Feb       Impact factor: 2.624

Review 2.  Myositis-associated interstitial lung disease: a comprehensive approach to diagnosis and management.

Authors:  Robert W Hallowell; Julie J Paik
Journal:  Clin Exp Rheumatol       Date:  2021-03-25       Impact factor: 4.473

3.  Comparison of gene expression profiling between lung fibrotic and emphysematous tissues sampled from patients with combined pulmonary fibrosis and emphysema.

Authors:  Masayuki Hanaoka; Michiko Ito; Yunden Droma; Atsuhito Ushiki; Yoshiaki Kitaguchi; Masanori Yasuo; Keishi Kubo
Journal:  Fibrogenesis Tissue Repair       Date:  2012-10-01

4.  The Association of Anti-Aminoacyl-Transfer Ribonucleic Acid Synthetase Antibodies in Patients With Rheumatoid Arthritis and Interstitial Lung Disease.

Authors:  Masakazu Matsushita; Naoto Tamura; Michihiro Ogasawara; Kurisu Tada; Ken Yamaji; Yoshinari Takasaki
Journal:  Arch Rheumatol       Date:  2017-10-12       Impact factor: 1.472

5.  Immunolocalization of Keratan Sulfate in Rat Spinal Tissues Using the Keratanase Generated BKS-1(+) Neoepitope: Correlation of Expression Patterns with the Class II SLRPs, Lumican and Keratocan.

Authors:  Anthony J Hayes; James Melrose
Journal:  Cells       Date:  2020-03-30       Impact factor: 6.600

Review 6.  Interstitial lung disease is a major characteristic of anti-KS associated ant-synthetase syndrome.

Authors:  Yongpeng Ge; Sizhao Li; Shanshan Li; Linrong He; Xin Lu; Guochun Wang
Journal:  Ther Adv Chronic Dis       Date:  2020-10-29       Impact factor: 5.091

7.  Prevalence of Novel Myositis Autoantibodies in a Large Cohort of Patients with Interstitial Lung Disease.

Authors:  Sofia A Moll; Mark G J P Platenburg; Anouk C M Platteel; Adriane D M Vorselaars; Montse Janssen Bonàs; Claudia Roodenburg-Benschop; Bob Meek; Coline H M van Moorsel; Jan C Grutters
Journal:  J Clin Med       Date:  2020-09-11       Impact factor: 4.241
  7 in total

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