Literature DB >> 19651803

Antioxidant effect of polyphenolic glabridin on LDL oxidation.

E Carmeli1, Y Fogelman.   

Abstract

This study was conducted to determine the effect of a natural polyphenolic isoflavone antioxidant (Glabridin) on low-density lipoprotein (LDL) oxidation. Determination of the extent of LDL oxidation was done by measuring the formation of Thiobarbituric acid reactive substances (TBARS). After oral administration of licorice-root ethanol extract to healthy subjects for 6 months, the subjects' oxidative stress level as well as plasma LDL oxidation reduced by 20%. We concluded that dietary consumption of glabridin protects LDL from oxidation.

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Year:  2009        PMID： 19651803     DOI： 10.1177/0748233709103034

Source DB:  PubMed          Journal:  Toxicol Ind Health        ISSN： 0748-2337            Impact factor:   2.273


  14 in total

Review 1.  A plant-based diet, atherogenesis, and coronary artery disease prevention.

Authors:  Phillip Tuso; Scott R Stoll; William W Li
Journal:  Perm J       Date:  2014-11-24

Review 2.  Phytochemistry and biological properties of glabridin.

Authors:  Charlotte Simmler; Guido F Pauli; Shao-Nong Chen
Journal:  Fitoterapia       Date:  2013-07-10       Impact factor: 2.882

3.  AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.

Authors:  Joo-Won Lee; Sung Sik Choe; Hagoon Jang; Jiyeong Kim; Hyun Woo Jeong; Hyunsun Jo; Kyeong-Hoon Jeong; Surendar Tadi; Myoung Gyu Park; Tae Hwan Kwak; Jin Man Kim; Dong-Hoon Hyun; Jae Bum Kim
Journal:  J Lipid Res       Date:  2012-04-09       Impact factor: 5.922

4.  Metabolic Profiling of Glabridin in Rat Plasma, Urine, Bile, and Feces After Intragastric and Intravenous Administration.

Authors:  Shundi Liu; Hao Lin; Yu Chen; Yuzhen Wang; Xiaoshan Zhang; Zheng Xiang; Xiaojun Cai
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2022-09-15       Impact factor: 2.569

Review 5.  Flavonoids as dietary regulators of nuclear receptor activity.

Authors:  Yishai Avior; David Bomze; Ory Ramon; Yaakov Nahmias
Journal:  Food Funct       Date:  2013-04-19       Impact factor: 5.396

Review 6.  Plant-Based Nutrition: An Essential Component of Cardiovascular Disease Prevention and Management.

Authors:  Hena Patel; Sonal Chandra; Sarah Alexander; Jeffrey Soble; Kim Allan Williams
Journal:  Curr Cardiol Rep       Date:  2017-09-08       Impact factor: 2.931

7.  Glabridin inhibits migration and invasion by transcriptional inhibition of matrix metalloproteinase 9 through modulation of NF-κB and AP-1 activity in human liver cancer cells.

Authors:  Ming-Ju Hsieh; Chiao-Wen Lin; Shun-Fa Yang; Mu-Kuan Chen; Hui-Ling Chiou
Journal:  Br J Pharmacol       Date:  2014-06       Impact factor: 8.739

8.  Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells.

Authors:  Hsin-Lien Huang; Ming-Ju Hsieh; Ming-Hsien Chien; Hui-Yu Chen; Shun-Fa Yang; Pei-Ching Hsiao
Journal:  PLoS One       Date:  2014-06-05       Impact factor: 3.240

9.  Glabridin attenuates the migratory and invasive capacity of breast cancer cells by activating microRNA-200c.

Authors:  Xianqing Ye; Fei Jiang; Yuan Li; Juan Mu; Lu Si; Xingxing Wang; Shilong Ning; Zhong Li
Journal:  Cancer Sci       Date:  2014-05-21       Impact factor: 6.716

10.  Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: decreased CIMT, reduced plasma lipid levels, and decreased blood pressure.

Authors:  Yacov Fogelman; Diana Gaitini; Eli Carmeli
Journal:  Food Nutr Res       Date:  2016-04-22       Impact factor: 3.894
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