OBJECTIVES/HYPOTHESIS: In suspected cases of Sjogren syndrome (SS), patients are often referred for a labial minor salivary gland biopsy. However, studies have shown this test to be unreliable. Pathologic misinterpretation and immunosuppressive medications may affect the results of the biopsy. As a result, it is best to perform this procedure only when necessary. The purpose of the current study was to review clinical signs and symptoms of patients who underwent a lip biopsy to determine which patients benefited most from this procedure. STUDY DESIGN: Retrospective review. METHODS: A retrospective chart review of patients referred to otolaryngology for a lip biopsy for the diagnosis of SS. RESULTS: Joint pain, salivary gland swelling, and abnormal serology (anti-Sjogren syndrome A/anti-Sjogren syndrome B) were more prevalent in the positive lip biopsy group (grade = 3 or 4). Out of the 12 patients who had both sicca symptoms and positive serology, nine (75%) had a grade = 4. Presence of sicca symptoms and positive serology were predictive of a positive biopsy (P = .017). Excluding those patients who were on immunosuppression for more than 6 weeks prior to the biopsy, the correlation became stronger (P = .011). CONCLUSIONS: In this study, clinical presentation of sicca symptoms and positive serology reliably predicted the results of a lip biopsy. The results of this study suggest that patients with clear criterion for SS may not require a lip biopsy, especially those patients on immunosuppression. When physicians suspect SS, a thorough clinical and laboratory examination is necessary to determine if a patient will benefit from a minor salivary gland biopsy.
OBJECTIVES/HYPOTHESIS: In suspected cases of Sjogren syndrome (SS), patients are often referred for a labial minor salivary gland biopsy. However, studies have shown this test to be unreliable. Pathologic misinterpretation and immunosuppressive medications may affect the results of the biopsy. As a result, it is best to perform this procedure only when necessary. The purpose of the current study was to review clinical signs and symptoms of patients who underwent a lip biopsy to determine which patients benefited most from this procedure. STUDY DESIGN: Retrospective review. METHODS: A retrospective chart review of patients referred to otolaryngology for a lip biopsy for the diagnosis of SS. RESULTS: Joint pain, salivary gland swelling, and abnormal serology (anti-Sjogren syndrome A/anti-Sjogren syndrome B) were more prevalent in the positive lip biopsy group (grade = 3 or 4). Out of the 12 patients who had both sicca symptoms and positive serology, nine (75%) had a grade = 4. Presence of sicca symptoms and positive serology were predictive of a positive biopsy (P = .017). Excluding those patients who were on immunosuppression for more than 6 weeks prior to the biopsy, the correlation became stronger (P = .011). CONCLUSIONS: In this study, clinical presentation of sicca symptoms and positive serology reliably predicted the results of a lip biopsy. The results of this study suggest that patients with clear criterion for SS may not require a lip biopsy, especially those patients on immunosuppression. When physicians suspect SS, a thorough clinical and laboratory examination is necessary to determine if a patient will benefit from a minor salivary gland biopsy.
Authors: Ireneusz Grulkowski; Jan K Nowak; Karol Karnowski; Paweł Zebryk; Mariusz Puszczewicz; Jaroslaw Walkowiak; Maciej Wojtkowski Journal: Biomed Opt Express Date: 2013-12-16 Impact factor: 3.732
Authors: Nadera J Sweiss; Karen Patterson; Ray Sawaqed; Umair Jabbar; Peter Korsten; Kyle Hogarth; Robert Wollman; Joe G N Garcia; Timothy B Niewold; Robert P Baughman Journal: Semin Respir Crit Care Med Date: 2010-07-27 Impact factor: 3.119
Authors: M Hermet; M André; J L Kémény; G Le Guenno; P Déchelotte; G Guettrot-Imbert; A Tridon; I Delèvaux; M Soubrier; O Aumaître Journal: Int J Rheumatol Date: 2012-10-16
Authors: Dewi van Stein-Callenfels; Jonathan Tan; Elisabeth Bloemena; Richard M van Vugt; Alexandre E Voskuyl; Nathalie T Y Santana; Isaäc van der Waal Journal: Med Oral Patol Oral Cir Bucal Date: 2014-07-01