Literature DB >> 19649807

Semisynthesis of Taxol.

P G Wuts1.   

Abstract

The semisynthesis of Taxol was critical to its development as a drug. This review focuses on methods that have been developed to convert the readily available 10-deacetylbaccatin III (10-DAB) into Taxol, highlighting the various protection schemes used for the phenylisoserine side chain and 10-DAB, along with the methods developed for the conjoining of the side chain to the hindered C-13 hydroxyl of the diterpenoid framework.

Entities:  

Year:  1998        PMID： 19649807

Source DB:  PubMed          Journal:  Curr Opin Drug Discov Devel        ISSN： 1367-6733


  6 in total

1.  Random sequencing of an induced Taxus cell cDNA library for identification of clones involved in Taxol biosynthesis.

Authors:  Stefan Jennewein; Mark R Wildung; MyDoanh Chau; Kevin Walker; Rodney Croteau
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-03       Impact factor: 11.205

2.  Taxol biosynthesis and molecular genetics.

Authors:  Rodney Croteau; Raymond E B Ketchum; Robert M Long; Rüdiger Kaspera; Mark R Wildung
Journal:  Phytochem Rev       Date:  2006-02       Impact factor: 5.374

Review 3.  Recent advances towards development and commercialization of plant cell culture processes for the synthesis of biomolecules.

Authors:  Sarah A Wilson; Susan C Roberts
Journal:  Plant Biotechnol J       Date:  2011-11-08       Impact factor: 9.803

Review 4.  Diversity through semisynthesis: the chemistry and biological activity of semisynthetic epothilone derivatives.

Authors:  Karl-Heinz Altmann; Fabienne Z Gaugaz; Raphael Schiess
Journal:  Mol Divers       Date:  2011-01-01       Impact factor: 2.943

5.  Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis.

Authors:  Robert M Long; Chandraiah Lagisetti; Robert M Coates; Rodney B Croteau
Journal:  Arch Biochem Biophys       Date:  2008-06-28       Impact factor: 4.013

6.  Metabolic Engineering of Bacillus subtilis Toward Taxadiene Biosynthesis as the First Committed Step for Taxol Production.

Authors:  Ingy I Abdallah; Hegar Pramastya; Ronald van Merkerk; Wim J Quax
Journal:  Front Microbiol       Date:  2019-02-20       Impact factor: 5.640
  6 in total

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