Literature DB >> 19648977

SASPense and DDRama in cancer and ageing.

Marzia Fumagalli1, Fabrizio d'Adda di Fagagna.   

Abstract

Senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.

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Year:  2009        PMID： 19648977     DOI： 10.1038/ncb0809-921

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  16 in total

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Authors:  W B Ershler; E T Keller
Journal:  Annu Rev Med       Date:  2000       Impact factor: 13.739

2.  Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

Authors:  Derrick J Rossi; David Bryder; Jun Seita; Andre Nussenzweig; Jan Hoeijmakers; Irving L Weissman
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

Review 3.  Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.

Authors:  Judith Campisi
Journal:  Cell       Date:  2005-02-25       Impact factor: 41.582

4.  Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

Authors:  Francis Rodier; Jean-Philippe Coppé; Christopher K Patil; Wieteke A M Hoeijmakers; Denise P Muñoz; Saba R Raza; Adam Freund; Eric Campeau; Albert R Davalos; Judith Campisi
Journal:  Nat Cell Biol       Date:  2009-07-13       Impact factor: 28.824

Review 5.  A role for CXCR2 in senescence, but what about in cancer?

Authors:  Juan C Acosta; Jesús Gil
Journal:  Cancer Res       Date:  2009-03-10       Impact factor: 12.701

6.  Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease.

Authors:  Hong Jiang; Eric Schiffer; Zhangfa Song; Jianwei Wang; Petra Zürbig; Kathrin Thedieck; Suzette Moes; Heike Bantel; Nadja Saal; Justyna Jantos; Meiken Brecht; Paul Jenö; Michael N Hall; Klaus Hager; Michael P Manns; Hartmut Hecker; Arnold Ganser; Konstanze Döhner; Andrzej Bartke; Christoph Meissner; Harald Mischak; Zhenyu Ju; K Lenhard Rudolph
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-11       Impact factor: 11.205

7.  Chemokine signaling via the CXCR2 receptor reinforces senescence.

Authors:  Juan C Acosta; Ana O'Loghlen; Ana Banito; Maria V Guijarro; Arnaud Augert; Selina Raguz; Marzia Fumagalli; Marco Da Costa; Celia Brown; Nikolay Popov; Yoshihiro Takatsu; Jonathan Melamed; Fabrizio d'Adda di Fagagna; David Bernard; Eva Hernando; Jesús Gil
Journal:  Cell       Date:  2008-06-13       Impact factor: 41.582

8.  Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Authors:  Thomas Kuilman; Chrysiis Michaloglou; Liesbeth C W Vredeveld; Sirith Douma; Remco van Doorn; Christophe J Desmet; Lucien A Aarden; Wolter J Mooi; Daniel S Peeper
Journal:  Cell       Date:  2008-06-13       Impact factor: 41.582

Review 9.  An oncogene-induced DNA damage model for cancer development.

Authors:  Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
Journal:  Science       Date:  2008-03-07       Impact factor: 47.728

10.  Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.

Authors:  Narendra Wajapeyee; Ryan W Serra; Xiaochun Zhu; Meera Mahalingam; Michael R Green
Journal:  Cell       Date:  2008-02-08       Impact factor: 41.582
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  40 in total

1.  Modulation of inflammatory markers by miR-146a during replicative senescence in trabecular meshwork cells.

Authors:  Guorong Li; Coralia Luna; Jianming Qiu; David L Epstein; Pedro Gonzalez
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-01-06       Impact factor: 4.799

2.  Constitutive secretion in Tetrahymena thermophila.

Authors:  Catherine L Madinger; Kathleen Collins; Lauren G Fields; Christopher H Taron; Jack S Benner
Journal:  Eukaryot Cell       Date:  2010-03-26

3.  POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway.

Authors:  J H Cho; M J Kim; K J Kim; J-R Kim
Journal:  Cell Death Differ       Date:  2011-11-04       Impact factor: 15.828

4.  Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress.

Authors:  Gireedhar Venkatachalam; Uttam Surana; Marie-Véronique Clément
Journal:  Nucleic Acids Res       Date:  2017-10-13       Impact factor: 16.971

5.  Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase.

Authors:  Salim Abdisalaam; Souparno Bhattacharya; Shibani Mukherjee; Debapriya Sinha; Kalayarasan Srinivasan; Mingrui Zhu; Esra A Akbay; Hesham A Sadek; Jerry W Shay; Aroumougame Asaithamby
Journal:  J Biol Chem       Date:  2020-06-15       Impact factor: 5.157

6.  Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation.

Authors:  Rosa Ana Risques; Lisa A Lai; Cigdem Himmetoglu; Anoosheh Ebaee; Lin Li; Ziding Feng; Mary P Bronner; Bassel Al-Lahham; Kris V Kowdley; Keith D Lindor; Peter S Rabinovitch; Teresa A Brentnall
Journal:  Cancer Res       Date:  2011-03-01       Impact factor: 12.701

7.  Aldosterone induces p21-regulated apoptosis via increased synthesis and secretion of tumour necrosis factor-α in human proximal tubular cells.

Authors:  Kento Kitada; Daisuke Nakano; Hirofumi Hitomi; Hiroyuki Kobori; Kazushi Deguchi; Hirohito Mori; Tsutomu Masaki; Akira Nishiyama
Journal:  Clin Exp Pharmacol Physiol       Date:  2012-10       Impact factor: 2.557

8.  Transcriptomics of cortical gray matter thickness decline during normal aging.

Authors:  P Kochunov; J Charlesworth; A Winkler; L E Hong; T E Nichols; J E Curran; E Sprooten; N Jahanshad; P M Thompson; M P Johnson; J W Kent; B A Landman; B Mitchell; S A Cole; T D Dyer; E K Moses; H H H Goring; L Almasy; R Duggirala; R L Olvera; D C Glahn; J Blangero
Journal:  Neuroimage       Date:  2013-05-24       Impact factor: 6.556

9.  MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype.

Authors:  Hongshan Chen; Penelope D Ruiz; Wendy M McKimpson; Leonid Novikov; Richard N Kitsis; Matthew J Gamble
Journal:  Mol Cell       Date:  2015-08-20       Impact factor: 17.970

10.  Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence.

Authors:  A-w Shao; H Sun; Y Geng; Q Peng; P Wang; J Chen; T Xiong; R Cao; J Tang
Journal:  Cell Death Differ       Date:  2016-01-22       Impact factor: 15.828
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