| Literature DB >> 19648918 |
Laufey Amundadottir, Peter Kraft, Rachael Z Stolzenberg-Solomon, Charles S Fuchs, Gloria M Petersen, Alan A Arslan, H Bas Bueno-de-Mesquita, Myron Gross, Kathy Helzlsouer, Eric J Jacobs, Andrea LaCroix, Wei Zheng, Demetrius Albanes, William Bamlet, Christine D Berg, Franco Berrino, Sheila Bingham, Julie E Buring, Paige M Bracci, Federico Canzian, Françoise Clavel-Chapelon, Sandra Clipp, Michelle Cotterchio, Mariza de Andrade, Eric J Duell, John W Fox, Steven Gallinger, J Michael Gaziano, Edward L Giovannucci, Michael Goggins, Carlos A González, Göran Hallmans, Susan E Hankinson, Manal Hassan, Elizabeth A Holly, David J Hunter, Amy Hutchinson, Rebecca Jackson, Kevin B Jacobs, Mazda Jenab, Rudolf Kaaks, Alison P Klein, Charles Kooperberg, Robert C Kurtz, Donghui Li, Shannon M Lynch, Margaret Mandelson, Robert R McWilliams, Julie B Mendelsohn, Dominique S Michaud, Sara H Olson, Kim Overvad, Alpa V Patel, Petra H M Peeters, Aleksandar Rajkovic, Elio Riboli, Harvey A Risch, Xiao-Ou Shu, Gilles Thomas, Geoffrey S Tobias, Dimitrios Trichopoulos, Stephen K Van Den Eeden, Jarmo Virtamo, Jean Wactawski-Wende, Brian M Wolpin, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Stephen J Chanock, Patricia Hartge, Robert N Hoover.
Abstract
We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 558,542 SNPs in 1,896 individuals with pancreatic cancer and 1,939 controls drawn from 12 prospective cohorts plus one hospital-based case-control study. We conducted a combined analysis of these groups plus an additional 2,457 affected individuals and 2,654 controls from eight case-control studies, adjusting for study, sex, ancestry and five principal components. We identified an association between a locus on 9q34 and pancreatic cancer marked by the SNP rs505922 (combined P = 5.37 x 10(-8); multiplicative per-allele odds ratio 1.20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene. Our results are consistent with earlier epidemiologic evidence suggesting that people with blood group O may have a lower risk of pancreatic cancer than those with groups A or B.Entities:
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Year: 2009 PMID： 19648918 PMCID： PMC2839871 DOI： 10.1038/ng.429
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330