Literature DB >> 1964838

Regulation of the NMDA receptor by redox phenomena: inhibitory role of ascorbate.

M D Majewska1, J A Bell, E D London.   

Abstract

Redox phenomena seem to modulate activity of the N-methyl-D-aspartate receptor. Some reductants (ascorbate, hydroquinone) inhibit, while others (dithiothreitol, mercaptoethanol, penicillamine) potentiate NMDA receptor function. Ascorbate inhibits binding of [3H]glutamate and [3H]thienylcycohexylpiperidine to the NMDA receptor complex, and impedes NMDA-gated currents in isolated neurons; dithiothreitol-like reductants enhance NMDA-induced currents. The ability of reductants to alter function of the NMDA receptor is abolished by oxidation.

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Year:  1990        PMID： 1964838     DOI： 10.1016/0006-8993(90)90379-p

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  35 in total

1.  A comparative study between a brain Na+,K(+)-ATPase inhibitor (endobain E) and ascorbic acid.

Authors:  G Rodríguez de Lores Arnaiz; T Herbin; C Peña
Journal:  Neurochem Res       Date:  2003-06       Impact factor: 3.996

2.  An electron spin resonance study for real-time detection of ascorbyl free radicals after addition of dimethyl sulfoxide in murine hippocampus or plasma during kainic acid-induced seizures.

Authors:  Shigekiyo Matsumoto; Chihiro Shingu; Hironori Koga; Satoshi Hagiwara; Hideo Iwasaka; Takayuki Noguchi; Isao Yokoi
Journal:  Neurochem Res       Date:  2010-03-25       Impact factor: 3.996

3.  Allosteric modulation of retinal GABA receptors by ascorbic acid.

Authors:  Cecilia I Calero; Evan Vickers; Gustavo Moraga Cid; Luis G Aguayo; Henrique von Gersdorff; Daniel J Calvo
Journal:  J Neurosci       Date:  2011-06-29       Impact factor: 6.167

4.  Effects of oleuropein on pentylenetetrazol-induced seizures in mice: involvement of opioidergic and nitrergic systems.

Authors:  Nastaran Rahimi; Bahram Delfan; Nazgol Motamed-Gorji; Ahmad R Dehpour
Journal:  J Nat Med       Date:  2017-01-19       Impact factor: 2.343

Review 5.  Vitamin C transport and its role in the central nervous system.

Authors:  James M May
Journal:  Subcell Biochem       Date:  2012

6.  Positive modulation of the α9α10 nicotinic cholinergic receptor by ascorbic acid.

Authors:  J C Boffi; C Wedemeyer; M Lipovsek; E Katz; D J Calvo; A B Elgoyhen
Journal:  Br J Pharmacol       Date:  2013-02       Impact factor: 8.739

7.  Nitric oxide modulates sodium vitamin C transporter 2 (SVCT-2) protein expression via protein kinase G (PKG) and nuclear factor-κB (NF-κB).

Authors:  Camila Cabral Portugal; Thaísa Godinho da Encarnação; Renato Socodato; Sarah Rodrigues Moreira; Dan Brudzewsky; António Francisco Ambrósio; Roberto Paes-de-Carvalho
Journal:  J Biol Chem       Date:  2011-10-31       Impact factor: 5.157

8.  On the mechanism of d-amphetamine-induced changes in glutamate, ascorbic acid and uric acid release in the striatum of freely moving rats.

Authors:  M Miele; M A Mura; P Enrico; G Esposito; P A Serra; R Migheli; D Zangani; E Miele; M S Desole
Journal:  Br J Pharmacol       Date:  2000-02       Impact factor: 8.739

9.  Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slices.

Authors:  M Reiser; L Schild; G Keilhoff; G Wolf
Journal:  Neurochem Res       Date:  1999-01       Impact factor: 3.996

10.  The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro.

Authors:  L H Tang; E Aizenman
Journal:  J Physiol       Date:  1993-06       Impact factor: 5.182
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