Literature DB >> 1964817

Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.

K Varga1, G Kunos.   

Abstract

Ethanol administered i.v. or into the nucleus tractus solitarii (NTS) of rats anaesthetized with urethane inhibits baroreflex bradycardia elicited by phenylephrine. This effect is prevented or reduced by pretreatment of rats with 3-mercaptopropionic acid, bicuculline, or RO 15-4513. Intra-NTS injection of muscimol also inhibits baroreflex bradycardia and causes a pressor response which is potentiated by intra-NTS ethanol. It is proposed that ethanol inhibits baroreflex bradycardia, at least in part, by potentiating the action of endogenous gamma-aminobutyric acid (GABA) at GABAA receptors in the NTS or its vicinity.

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Year:  1990        PMID： 1964817      PMCID： PMC1917857          DOI： 10.1111/j.1476-5381.1990.tb14155.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Is L-glutamate a neurotransmitter of baroreceptor information in the nucleus of the tractus solitarius?

Authors:  C Leone; F J Gordon
Journal:  J Pharmacol Exp Ther       Date:  1989-09       Impact factor: 4.030

2.  Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.

Authors:  P D Suzdak; R D Schwartz; P Skolnick; S M Paul
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

3.  Ethanol inhibits NMDA-activated ion current in hippocampal neurons.

Authors:  D M Lovinger; G White; F F Weight
Journal:  Science       Date:  1989-03-31       Impact factor: 47.728

4.  The effect of 3-mercaptopropionate, an inhibitor of glutamate decarboxylase, on the levels of GABA and other amino acids, and on presynaptic inhibition in the rat cuneate nucleus.

Authors:  F Roberts; P V Taberner; R G Hill
Journal:  Neuropharmacology       Date:  1978-09       Impact factor: 5.250

5.  Picrotoxin- and bicuculline-sensitive inhibition of cardiac vagal reflexes.

Authors:  S M Barman; G L Gebber
Journal:  J Pharmacol Exp Ther       Date:  1979-04       Impact factor: 4.030

6.  Activation of brainstem endorphinergic neurons causes cardiovascular depression and facilitates baroreflex bradycardia.

Authors:  J A Mastrianni; M Palkovits; G Kunos
Journal:  Neuroscience       Date:  1989       Impact factor: 3.590

Review 7.  Molecular interactions of ethanol with GABAergic system and potential of RO15-4513 as an ethanol antagonist.

Authors:  M K Ticku; S K Kulkarni
Journal:  Pharmacol Biochem Behav       Date:  1988-06       Impact factor: 3.533

8.  Pressor effect of alcohol in hypertension.

Authors:  J F Potter; D G Beevers
Journal:  Lancet       Date:  1984-01-21       Impact factor: 79.321

9.  Medullary gamma-aminobutyric acid (GABA) receptors and the regulation of blood pressure in the rat.

Authors:  R N Willette; A J Krieger; P P Barcas; H N Sapru
Journal:  J Pharmacol Exp Ther       Date:  1983-09       Impact factor: 4.030

10.  Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol.

Authors:  X Zhang; A A Abdel-Rahman; W R Wooles
Journal:  Hypertension       Date:  1989-09       Impact factor: 10.190
  10 in total
  9 in total

Review 1.  Role of Alcohol Oxidative Metabolism in Its Cardiovascular and Autonomic Effects.

Authors:  Mahmoud M El-Mas; Abdel A Abdel-Rahman
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

Review 2.  Preventable deaths after injury: why are the traditional 'vital' signs poor indicators of blood loss?

Authors:  R A Little; E Kirkman; P Driscoll; J Hanson; K Mackway-Jones
Journal:  J Accid Emerg Med       Date:  1995-03

3.  Role of rostral ventrolateral medullary ERK/JNK/p38 MAPK signaling in the pressor effects of ethanol and its oxidative product acetaldehyde.

Authors:  Mahmoud M El-Mas; Ming Fan; Abdel A Abdel-Rahman
Journal:  Alcohol Clin Exp Res       Date:  2013-07-26       Impact factor: 3.455

4.  Bradykinin B2 receptor-dependent enhancement of enalapril-evoked hypotension in ethanol-fed female rats.

Authors:  Mahmoud M El-Mas; Abdel A Abdel-Rahman
Journal:  J Cardiovasc Pharmacol       Date:  2011-01       Impact factor: 3.105

5.  Central α7 and α4β2 nicotinic acetylcholine receptors offset arterial baroreceptor dysfunction in endotoxic rats.

Authors:  Marwa Y Sallam; Sahar M El-Gowilly; Mahmoud M El-Mas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-09-14       Impact factor: 3.195

6.  Facilitation of central imidazoline I(1)-site/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase signalling mediates the hypotensive effect of ethanol in rats with acute renal failure.

Authors:  Mahmoud M El-Mas; Hanan M El-Gowelli; Abdel-Rheem M Ghazal; Osama F Harraz; Mahmoud M Mohy El-Din
Journal:  Br J Pharmacol       Date:  2009-10-20       Impact factor: 8.739

7.  Ser/thr phosphatases tonically attenuate the ERK-dependent pressor effect of ethanol in the rostral ventrolateral medulla in normotensive rats.

Authors:  Mahmoud M El-Mas; Abdel A Abdel-Rahman
Journal:  Brain Res       Date:  2014-06-28       Impact factor: 3.252

8.  A total closed chest sheep model of cardiogenic shock by percutaneous intracoronary ethanol injection.

Authors:  Mario Rienzo; Julien Imbault; Younes El Boustani; Antoine Beurton; Carolina Carlos Sampedrano; Philippe Pasdois; Mathieu Pernot; Olivier Bernus; Michel Haïssaguerre; Thierry Couffinhal; Alexandre Ouattara
Journal:  Sci Rep       Date:  2020-07-24       Impact factor: 4.379

9.  Role of neuronal nitric oxide synthase (nNOS) at medulla in tachycardia induced by repeated administration of ethanol in conscious rats.

Authors:  Jiro Hasegawa Situmorang; Hsun-Hsun Lin; Hsuan Lo; Chih-Chia Lai
Journal:  J Biomed Sci       Date:  2018-01-31       Impact factor: 8.410
  9 in total

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